Evidence map›Paper›PMID 34009122›Full record

ArticleeLife2021

Metal microdrive and head cap system for silicon probe recovery in freely moving rodent.

Mihály Vöröslakos, Peter C Petersen, Balázs Vöröslakos, György Buzsáki

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
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  4. Dynamics of Dentate Gyrus Place Cells and Dentate Spikes during Spatial and Nonspatial Changes in Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  12. Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  15. Article
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  18. The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mihály Vöröslakos *Neuroscience Institute, New York University, New York, United States.ORCID 0000-0002-1022-1355
Peter C Petersen *Neuroscience Institute, New York University, New York, United States.ORCID 0000-0002-2092-4791
Balázs Vöröslakos *Budapest University of Technology and Economics, Faculty of Mechanical Engineering, Budapest, Hungary.
György BuzsákiNeuroscience Institute, New York University, New York, United States.ORCID 0000-0002-3100-4800
Neurosciences Institute · USBudapest University of Technology and Economics · HU

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI SOLTESZ, IVAN · 2017 to 2021
$13.2M
Transformation of Neuronal Activity in the Entorhinal-hippocampal-neocortex PathR01MH122391 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BASU, JAYEETA, BUZSAKI, GYORGY · 2020 to 2024
$3.3M
NIMH NIH HHS R01 MH122391NINDS NIH HHS U19 NS104590NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

High-yield electrophysiological extracellular recording in freely moving rodents provides a unique window into the temporal dynamics of neural circuits. Recording from unrestrained animals is critical to investigate brain activity during natural behaviors. The use and implantation of high-channel-count silicon probes represent the largest cost and experimental complexity associated with such recordings making a recoverable and reusable system desirable. To address this, we have designed and tested a novel 3D printed head-gear system for freely moving mice and rats. The system consists of a recoverable microdrive printed in stainless steel and a plastic head cap system, allowing researchers to reuse the silicon probes with ease, decreasing the effective cost, and the experimental effort and complexity. The cap designs are modular and provide structural protection and electrical shielding to the implanted hardware and electronics. We provide detailed procedural instructions allowing researchers to adapt and flexibly modify the head-gear system.

Indexed as

Action PotentialsElectrodes, ImplantedLocomotionMetalsMicroelectrodesSiliconesAnimalsBehavior, AnimalBrainDevice RemovalElectroencephalographyEquipment DesignEquipment ReuseMaleMaterials TestingMiceMetalsSiliconesbehaviorelectrophysiologyfreely movingmicrodrivemouseneuroscienceratsilicon probe

Identifiers

PMID34009122
PMCPMC8177890
OpenAlexW3163035583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.