Evidence map›Paper›PMID 34009063›Full record

ArticleJournal of dental research2022

Alveolar Bone Marrow Gli1+ Stem Cells Support Implant Osseointegration.

Y Yi, W Stenberg, W Luo, J Q Feng, H Zhao

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Targeting Gli1Stem cell reviews and reports · 2026
    Review
  2. Article
  3. Stem-cell regulation in periodontium formation and regeneration.Journal of bone and mineral metabolism · 2026
    Review
  4. Article
  5. Mesenchymal Stem Cells in Socket Healing and MRONJ.Orthodontics & craniofacial research · 2025
    Review
  6. O-GlcNAcylation in Gli1International journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Differentiation potential of periodontal Col1Mechanobiology in medicine · 2024
    Article
  11. Gli1Journal of dental research · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. The Role of Gli1Biomolecules · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Y YiDepartment of Comprehensive Dentistry, College of Dentistry, Texas A&M University, Dallas, TX, USA.
W StenbergDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
W LuoDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
J Q FengDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
H ZhaoDepartment of Comprehensive Dentistry, College of Dentistry, Texas A&M University, Dallas, TX, USA.
Texas A&M University · USSichuan University · CN

Funding

Regulating niche of periodontium mesenchymal stem cells under the physiological conditionR01DE028291 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FENG, JIAN Q. · 2019 to 2022
$1.1M
Utilizing tissue clearing based 3-D imaging to quantitatively study neural regulation of craniofacial mesenchymal stem cellsR21DE027928 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FENG, JIAN Q. · 2018 to 2019
$408k
The tendon cell is a robust alternative lineage for bone repair upon trauma or inflammationR01DE030643 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FENG, JIAN Q. · 2021 to 2022
$369k
NIDCR NIH HHS R01 DE028291NIDCR NIH HHS R01 DE030643NIDCR NIH HHS R21 DE027928
6 · The paper itself

Abstract

Osseointegration is the key issue for implant success. The in vivo properties of cell populations driving the osseointegration process have remained largely unknown. In the current study, using tissue clearing-based 3-dimensional imaging and transgenic mouse model-based lineage tracing methods, we identified Gli1+ cells within alveolar bone marrow and their progeny as the cell population participating in extraction socket healing and implant osseointegration. These Gli1

Indexed as

Dental ImplantsOsseointegrationAnimalsBone MarrowDental Implantation, EndosseousMiceStem CellsTooth ExtractionTooth SocketZinc Finger Protein GLI1Dental ImplantsZinc Finger Protein GLI1alveolar bonebone-implant interfacedental implantationhedgehogsperiodontiumWnt signaling pathway

Identifiers

PMID34009063
PMCPMC8721727
OpenAlexW3163138585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.