ArticleEnvironmental health perspectives2021
DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.Environmental health perspectives · 2026Pooled it
- Child Salivary Cotinine Levels Related to Neighborhood Deprivation and Tobacco and Alcohol Retail Outlets.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Early-life tobacco exposure elevating childhood attention-deficit hyperactivity disorder risk: a two-sample Mendelian randomisation analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Smoking-Associated DNA Methylation and Offspring Caries Experience: Findings from the GUSTO Study.Journal of dental research · 2026Article
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Therapeutic potentials of natural products for post-traumatic stress disorder: A focus on epigenetics.Chinese herbal medicines · 2025Review
- Association of exposure to second-hand smoke during childhood with blood DNA methylation.Environment international · 2025Article
- Tobacco Exposures are Associated With Healthcare Utilization and Healthcare Costs in Pregnant Persons and Their Newborn Babies.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design.Developmental psychology · 2024Article
- Modeling the Effects of Policies that Restrict Tobacco Retail Outlets on Prenatal Smoke Exposure and Perinatal Health Care Utilization.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Tobacco Smoke Exposure in Early Childhood and Later Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study.Journal of Crohn's & colitis · 2024Article
- The association of cigarette smoking with DNA methylation and gene expression in human tissue samples.American journal of human genetics · 2024Article
- Air Pollution inside Vehicles: Making a Bad Situation Worse.International journal of environmental research and public health · 2023Article
- A biomechanical view of epigenetic tumor regulation.Journal of biological physics · 2023Review
- An epigenetic synopsis of parental substance use.Epigenomics · 2023Review
- Sex-specific DNA methylation and associations withEpigenetics · 2022Article
- Maternal depression and adverse neighbourhood conditions during pregnancy are associated with gestational epigenetic age deceleration.Epigenetics · 2022Article
- Tobacco Retail Outlets, Neighborhood Deprivation and the Risk of Prenatal Smoke Exposure.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Neighborhood Deprivation is Associated with Increased Risk of Prenatal Smoke Exposure.Prevention science : the official journal of the Society for Prevention Research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMaternal smoking during pregnancy is related to altered DNA methylation in infant umbilical cord blood. The extent to which low levels of smoke exposure among nonsmoking pregnant women relates to offspring DNA methylation is unknown.
objectiveThis study sought to evaluate relationships between maternal prenatal plasma cotinine levels and DNA methylation in umbilical cord blood in newborns using the Infinium HumanMethylation 450K BeadChip.
methodsParticipants from the Newborn Epigenetics Study cohort who reported not smoking during pregnancy had verified low levels of cotinine from maternal prenatal plasma (0
resultsMultivariable linear regression models yielded 29,049 CpGs that were differentially methylated in relation to increases in cotinine at a 5% false discovery rate. Top CpGs were within or near genes involved in neuronal functioning ( DISCUSSION: Secondhand smoke exposure among nonsmoking women may alter DNA methylation in regions involved in development, carcinogenesis, and neuronal functioning. These novel findings suggest that even low levels of smoke exposure during pregnancy may be sufficient to alter DNA methylation in distinct sites of mixed umbilical cord blood leukocytes in pathways that are known to be altered in cord blood from pregnant active smokers. https://doi.org/10.1289/EHP8099.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.