ArticleCell proliferation2021
Naringin-inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord-derived mesenchymal stem cell-based bone regeneration.
Article in Cell proliferation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies.International journal of molecular sciences · 2022Pooled it
- Naringin promotes angiogenesis in bone fracture healing via TAS2R39-CaJournal of translational medicine · 2026Article
- Integrating BMSC-inlaid GelMA hydrogels and melatonin-loaded PLGA microspheres into silk fibroin/nanohydroxyapatite scaffolds to repair osteoporotic bone defects.Journal of orthopaedic surgery and research · 2026Article
- Plant-derived extracellular vesicles in skin and bone tissue engineering: current status, challenges, and future perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.Stem cell research & therapy · 2025Article
- Fast shape memory function and personalized PLTMC/SIM/MBG composite scaffold for bone regeneration.Materials today. Bio · 2025Article
- Article
- Fibroin-Hybrid Systems: Current Advances in Biomedical Applications.Molecules (Basel, Switzerland) · 2025Review
- Review
- Flavonoid-Loaded Biomaterials in Bone Defect Repair.Molecules (Basel, Switzerland) · 2023Review
- Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations.ACS materials Au · 2023Review
- Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration.Advanced functional materials · 2023Article
- Thermosensitive hydrogel coupled with sodium ascorbyl phosphate promotes human umbilical cord-derived mesenchymal stem cell-mediated skin wound healing in mice.Scientific reports · 2023Article
- Article
- The Development of Naringin for Use against Bone and Cartilage Disorders.Molecules (Basel, Switzerland) · 2023Review
- Biomimetic, biodegradable and osteoinductive treated dentin matrix/α-calcium sulphate hemihydrate composite material for bone tissue engineering.Regenerative biomaterials · 2023Article
- Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair.Regenerative biomaterials · 2023Article
- Review
- Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled studyJournal of the Turkish German Gynecological Association · 2022Article
- Naringin Release from a Nano-Hydroxyapatite/Collagen Scaffold Promotes Osteogenesis and Bone Tissue Reconstruction.Polymers · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesLarge bone defects are a common, debilitating clinical condition that have substantial global health and economic burden. Bone tissue engineering technology has become one of the most promising approaches for regenerating defective bones. In this study, we fabricated a naringin-inlaid composite silk fibroin/hydroxyapatite (NG/SF/HAp) scaffold to repair bone defects. MATERIALS AND
methodsThe salt-leaching technology was used to fabricate the NG/SF/HAp scaffold. The cytocompatibility of the NG/SF/HAp scaffold was assessed using scanning electron microscopy, live/dead cell staining and phalloidin staining. The osteogenic and angiogenic properties were assessed in vitro and in vivo.
resultsThe porous NG/SF/HAp scaffold had a well-designed biomimetic porous structure with osteoinductive and angiogenic activities. A gene microarray identified 854 differentially expressed genes between human umbilical cord-derived mesenchymal stem cells (hUCMSCs) cultured on SF-nHAp scaffolds and cells cultured on NG/SF/HAp scaffolds. The underlying osteoblastic mechanism was investigated using hUCMSCs in vitro. Naringin facilitated hUCMSC ingrowth into the SF/HAp scaffold and promoted osteogenic differentiation. The osteogenic and angiogenic capabilities of cells cultured in the NG/SF/HAp scaffold were superior to those of cells cultured in the SF/HAp scaffold.
conclusionsThe data indicate the potential of the SF/HAp composite scaffold incorporating naringin for bone regeneration.
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Registered trials
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