ArticleJournal of applied oral science : revista FOB2021
The prevalence of novel periodontal pathogens and bacterial complexes in Stage II generalized periodontitis based on 16S rRNA next generation sequencing.
Article in Journal of applied oral science : revista FOB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Prevalence of species of yellow, purple and green microbial complexes in endo-perio lesions: a systematic review.Brazilian oral research · 2024Pooled it
- Review
- Microbial crosstalk along the oral-gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum.Neoplasia (New York, N.Y.) · 2026Review
- Periodontitis and respiratory infections - exploring the oral-systemic link.Annals of medicine and surgery (2012) · 2026Article
- From health to periodontitis: dynamic changes in the subgingival microbiome and their association with systemic inflammation levels.Frontiers in cellular and infection microbiology · 2026Article
- Sex-specific variations in subgingival microbiome of elderly patients with moderate periodontitis: an exploratory study.Frontiers in genetics · 2026Article
- Peridontopathogenic key species in correlation to the current classification system.Clinical oral investigations · 2025Article
- Evaluating the Impact of Kefir Consumption on Dental Caries and Periodontal Disease: A Narrative Review.Dentistry journal · 2025Review
- Article
- Alterations of the oral microbiota in mild Alzheimer's disease and the appropriate application of chlorhexidine gluconate.JAR life · 2025Article
- Exploring oral bacterial compositional network in two oral disease groups using a convergent approach of NGS-molecular diagnostics.Genes & genomics · 2024Article
- Correlation between Inflammasomes and Microbiota in Peri-Implantitis.International journal of molecular sciences · 2024Article
- Molecular commensalism: how oral corynebacteria and their extracellular membrane vesicles shape microbiome interactions.Frontiers in oral health · 2024Article
- Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies.Frontiers in microbiology · 2024Review
- Association of nine pathobionts with periodontitis in four South American and European countries.Journal of oral microbiology · 2023Article
- Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens.Journal of applied oral science : revista FOB · 2023Article
- Article
- Complete Genome Sequence of "Microbiology resource announcements · 2022Article
- Differences in the subgingival microbiome according to stage of periodontitis: A comparison of two geographic regions.PloS one · 2022Article
- Enrichment of sulphate-reducers and depletion of butyrate-producers may be hyperglycaemia signatures in the diabetic oral microbiome.Journal of oral microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define the subgingival microbial profile associated with Stage II generalized periodontitis using next-generation sequencing and to determine the relative abundance of novel periodontal pathogens and bacterial complexes. METHODOLOGY: Subgingival biofilm samples were collected from 80 subjects diagnosed with Stage II generalized periodontitis. Bacterial DNA was extracted, and 16S rRNA-based bacterial profiling via next-generation sequencing was carried out. The bacterial composition and diversity of microbial communities based on the age and sex of the patients were analyzed. The bacterial species were organized into groups: bacterial complexes (red, orange, purple, yellow, and green), novel periodontal pathogens, periodontal health-related species, and unclassified periodontal species. The results were analyzed and statistically evaluated.
resultsThe highest number of bacteria belonged to the phylum Bacteroidetes and Firmicutes. In terms of relative abundance, the orange complex represented 18.99%, novel bacterial species (Fretibacterium spp. and Saccharibacteria spp.) comprised 17.34%, periodontal health-related species accounted for 16.75% and unclassified periodontal species represented (Leptotrichia spp. and Selenomonas spp.) 15.61%. Novel periodontal pathogens had outweighed the periodontal disease-related red complex (5.3%). The one-sample z-test performed was statistically significant at p<0.05. The Beta diversity based on the unweighted UniFrac distance at the species level demonstrated a total variance of 15.77% based on age and 39.19% on sex, which was not statistically significant.
conclusionThe bacterial species corresponding to the disease-related orange complex and novel periodontal pathogens are predominant in Stage II generalized periodontitis.
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