Evidence map›Paper›PMID 34008442›Full record

ArticleJournal of diabetes science and technology2022

Comparing Patch vs Pen Bolus Insulin Delivery in Type 2 Diabetes Using Continuous Glucose Monitoring Metrics and Profiles.

Richard M Bergenstal, Mary L Johnson, Vanita R Aroda, Ronald L Brazg, Darlene M Dreon, Juan P Frias, Davida F Kruger, Mark E Molitch, Deborah M Mullen, Mark Peyrot and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Successful Implementation and Improved A1C With a Bolus-Only Insulin Patch Using 500 units/mL Regular Insulin.Clinical diabetes : a publication of the American Diabetes Association · 2025
    Article
  4. Insulin Pumps for Individuals With Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2025
    Article
  5. Review
  6. Patient Perspectives on the Benefits and Challenges of Diabetes and Digital Technology.Clinical diabetes : a publication of the American Diabetes Association · 2024
    Article
  7. A Safe and Simple Algorithm for Adding and Adjusting Mealtime Insulin to Basal-Only Therapy.Clinical diabetes : a publication of the American Diabetes Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

Richard M BergenstalInternational Diabetes Center, Park Nicollet, Minneapolis, MN, USA.ORCID 0000-0002-9050-5584
Mary L JohnsonInternational Diabetes Center, Park Nicollet, Minneapolis, MN, USA.
Vanita R ArodaMedstar Health Research Institute, Hyattsville, MD, USA.
Ronald L BrazgRainier Clinical Research Center, Renton, WA, USA.
Darlene M DreonCalibra Medical, Johnson & Johnson Diabetes Care Companies, Wayne, PA, USA.
Juan P FriasNational Research Institute, Los Angeles, CA, USA.
Davida F KrugerDivision of Endocrinology, Diabetes, Bone and Mineral Disease, Henry Ford Health System, Detroit, MI, USA.
Mark E MolitchDivision of Endocrinology, Metabolism and Molecular Medicine at the Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Deborah M MullenInternational Diabetes Center, Park Nicollet, Minneapolis, MN, USA.ORCID 0000-0001-6345-2889
Mark PeyrotLoyola University Maryland, Department of Sociology, Baltimore, MD, USA.
Sara RichterProfessional Data Analysts, GBC, Minneapolis, MN, USA.
Julio RosenstockDallas Diabetes Research Center at Medical City, Dallas, TX, USA.
Pierre SerusclatGroupe Hospitalier Mutualiste Les Portes du Sud, Ve'nissieux, France.
Carl VanceRocky Mountain Diabetes Center, Idaho Falls, Idaho, USA.
Ruth S WeinstockDepartment of Endocrinology, Diabetes and Metabolism, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0001-5859-5666
Brian L LevyCalibra Medical, Johnson & Johnson Diabetes Care Companies, Wayne, PA, USA.
Park Nicollet Clinic · USJohnson & Johnson (United States) · USDallas Diabetes Research Center · USGroupe Hospitalier Mutualiste de Grenoble · FRHenry Ford Health System · USLoyola University Maryland · USMedStar Health · USNational Research Institute · USNorthwestern University · USRainier Clinical Research Center · USRocky Mountain Diabetes and Osteoporosis Center · USSUNY Upstate Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCeQur Simplicity™ (CeQur, Marlborough, MA) is a 3-day insulin delivery patch designed to meet mealtime insulin requirements. A recently reported 48-week, randomized, multicenter, interventional trial compared efficacy, safety and self-reported outcomes in 278 adults with type 2 diabetes (T2D) on basal insulin therapy who initiated and managed mealtime insulin therapy with a patch pump versus insulin pen. We assessed changes in key glycemic metrics among a subset of patients who wore a continuous glucose monitoring (CGM) device.

methodsStudy participants (patch,

resultsBoth the patch and pen groups achieved recommended targets in %TIR (74.1% ± 18.7%, 75.2 ± 16.1%, respectively) and marked reductions in %TAR >180 mg/dL (21.1% ± 19.9%, 19.7% ± 17.5%, respectively) but with increased %TBR <70 mg/dL (4.7% ± 5.2%, 5.1 ± 5.8, respectively), all

conclusionsCGM confirmed that the patch or pen can be used to safely initiate and optimize basal-bolus therapy using a simple insulin adjustment algorithm with SMBG. Preference data suggest that use of the patch vs pen may enhance treatment adherence.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2AdultBlood GlucoseBlood Glucose Self-MonitoringGlycated HemoglobinHumansHypoglycemic AgentsInsulinBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinalgorithmCGMmealtime insulinpatchSMBGT2Dtime in rangeTIRtype 2 diabetes

Identifiers

PMID34008442
PMCPMC9445326
OpenAlexW3161721532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.