Evidence map›Paper›PMID 34008266›Full record

ArticleTropical medicine & international health : TM & IH2021

How many more? Under-reporting of the COVID-19 deaths in Brazil in 2020.

Emil Kupek

Open access · bronzeAbstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Impacts of the COVID-19 pandemic on excess deaths: descriptive study, Pernambuco, 2020-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
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  14. Evaluation of SARS-CoV-2 concentrations in wastewater and river water samples.Case studies in chemical and environmental engineering · 2022
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  15. Wastewater-based epidemiology: A Brazilian SARS-COV-2 surveillance experience.Journal of environmental chemical engineering · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Emil KupekDepartment of Public Health, Federal University of Santa Catarina, Florianopolis, Brazil.
Universidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the magnitude of under-reporting the number of deaths due to COVID-19 in Brazil in 2020, previously shown to occur due to low rate of laboratory testing for SARS-CoV-2, reporting delay, inadequate access to medical care, and its poor quality, leading to the low sensitivity of epidemiological surveillance and poor outcomes, often without laboratory confirmation of the cause of death.

methodsExcess mortality due to COVID-19 was estimated directly based on various data sources, and indirectly, based on the difference between the observed and expected number of deaths from serious acute respiratory infection (SARI) and all-natural causes in 2020 had there been no COVID-19. The absence of laboratory testing for SARS-CoV-2 was adjusted based on the proportion of those who tested positive among the tested individuals whose death was attributed to COVID-19. Least absolute shrinkage and selection operator (lasso) were used to improve prediction of likely mortality without COVID-19 in 2020.

resultsUnder-reporting of COVID-19 deaths was 22.62%, with a corresponding mortality rate per 100 000 inhabitants of 115 by the direct method, 71-76 by the indirect methods based on the excess SARI mortality and 95-104 by excess mortality due to natural causes. COVID-19 was the third cause of mortality that contributed directly with 18%, and indirectly with additional 10-11% to all deaths in Brazil in 2020.

conclusionsUnderestimation of COVID-19 mortality between 1:5 and 1:4 is likely its lower bound. Timely and accurate surveillance of death causes is of the essence to evaluate the COVID-19 burden.

Indexed as

Cause of DeathSARS-CoV-2BrazilCOVID-19HumansBrazilcauses of deathCOVID-19mortalitySARIunderreporting

Identifiers

PMID34008266
PMCPMC8242696
OpenAlexW3162417887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.