Evidence map›Paper›PMID 34008119›Full record

ArticleNeurochemical research2021

NADPH-Oxidase 2 Promotes Autophagy in Spinal Neurons During the Development of Morphine Tolerance.

Xuyang Xiao, Huilian Bu, Zhisong Li, Zheng Li, Qian Bai, Zhitao Wang, Lin Yan, Daiqiang Liu, Xiaoling Peng, Xiaoqian Jia and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. NADPH Oxidases in Pain Processing.Antioxidants (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xuyang Xiao *Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huilian Bu *Department of Pain Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhisong LiDepartment of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zheng LiDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qian BaiDepartment of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhitao WangDepartment of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lin YanDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Daiqiang LiuDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaoling PengDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaoqian JiaDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feng GaoDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. fgao@tjh.tjmu.edu.cn.ORCID http://orcid.org/0000-0001-8933-1663
Second Affiliated Hospital of Zhengzhou University · CNTongji Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

National Natural Science Foundation of China 81771191
6 · The paper itself

Abstract

Repeated morphine administration results in analgesic tolerance. However, the underlying mechanism of morphine analgesic tolerance remains unclear. NADPH-oxidase 2 (NOX2) is the first discovered NADPH oxidase, which mainly functions to produce reactive oxygen species. Its specific role in morphine tolerance has not been fully investigated. In this work, we found that chronic morphine administration significantly increased the expression of NOX2 in spinal cord. Pretreatment of NOX2 inhibitor blocked the upregulation of NOX2 and autophagy markers, including LC3B and P62, and consequently the development of morphine tolerance. NOX2 and LC3B were both colocalized with NeuN in spinal dorsal horn in morphine-tolerant rats. Our results suggest that the increased autophagy activity in spinal neurons promoted by NOX2 activation contributes to the development of morphine tolerance. NOX2 may be considered as a new therapeutic target for morphine tolerance.

Indexed as

Analgesics, OpioidAutophagyDrug ToleranceMorphineNADPH Oxidase 2NeuronsAnimalsMaleMicrotubule-Associated ProteinsOnium CompoundsRatsRats, Sprague-DawleySpinal Cord Dorsal HornAnalgesics, OpioidAnxa3 protein, ratCybb protein, ratdiphenyleneiodoniumMicrotubule-Associated ProteinsMorphineNADPH Oxidase 2Onium CompoundsAutophagyMorphine toleranceNADPH oxidaseReactive oxygen species

Identifiers

PMID34008119
OpenAlexW3161848965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.