ArticleTechnical innovations & patient support in radiation oncology2021
Impact of PTV margin reduction (2 mm to 0 mm) on pseudoprogression in stereotactic radiotherapy of solitary brain metastases.
Article in Technical innovations & patient support in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- Dose and clinical impact of delineation variability in brain metastases treated with stereotactic radiotherapy.Clinical and translational radiation oncology · 2026Article
- A multi-institutional survey on radiosurgery for multiple brain metastases in Latin America.Physical and engineering sciences in medicine · 2026Article
- Control-point-specific plan robustness in volumetric modulated arc therapy-based cranial radiotherapy.Journal of applied clinical medical physics · 2026Article
- Local recurrence and radionecrosis after single-isocenter multiple targets stereotactic radiotherapy for brain metastases.Scientific reports · 2025Article
- Spatial accuracy of dose delivery significantly impacts the planning target volume margin in linear accelerator-based intracranial stereotactic radiosurgery.Scientific reports · 2025Article
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- Treatment planning with high-resolution 3D dose maps in preclinical and translational synchrotron microbeam radiation therapy.Physics and imaging in radiation oncology · 2024Article
- Dose-effect relationship of linear accelerator based stereotactic radiotherapy for brain metastases.Radiation oncology (London, England) · 2023Article
- Comparison of 2 stereotactic radiotherapy regimens for brain metastases: Is higher always better?Neuro-oncology advancesArticle
- Dosimetric Analysis of Intra-Fraction Motion Detected by Surface-Guided Radiation Therapy During Linac Stereotactic Radiosurgery.Advances in radiation oncologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
purposeTo determine the influence of PTV-margin (0 mm versus 2 mm) on the incidence of pseudoprogression (PP) and local tumour control (LC) in patients treated with stereotactic radiotherapy (SRT) for solitary brain metastases.
methodsPatients were treated on Novalis LINAC. Three dose schedules were used depending on the PTV-size. The PTV-margin was 2-mm prior to 2015 and 0-mm thereafter. MRI-scans were made every three months including a perfusion MRI-scan when pseudoprogression was suspected. We examined the relation of pseudoprogression and local control with the size of PTV-margin. Besides this, the association of dose-volume data of the whole brain (minus GTV) and pseudoprogression was investigated.
results121 patients were analyzed (2-mm margin in 84 patients; 0-mm margin in 37 patients). There was no difference in GTV (7.6 cc versus 9.1 cc p = 0.2). At 24 months there was no difference in incidence of pseudoprogression (49% and versus 33%, p = 0.5) and local control in the 2-mm and 0-mm group (82% and versus 79%, p = 1.0). The size of PTV-margin was not associated with PP. Both margin and volume of brain receiving 12 Gy (V12) were not associated with pseudoprogression in patients treated with single fraction.
conclusionsPTV-margin reduction did not reduce the incidence of pseudoprogression in LINAC-based-SRT for single brain metastases. We did not find a significant association of GTV-PTV margin or V12Gy with the incidence of pseudoprogression in solitary metastases treated with a single fraction. LC rates were similar, indicating margin reduction seems to be safe.
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