Evidence map›Paper›PMID 34007453›Full record

ArticleNew microbes and new infections2021

The dark side of SARS-CoV-2 rapid antigen testing: screening asymptomatic patients.

G Caruana, L-L Lebrun, O Aebischer, O Opota, L Urbano, M de Rham, O Marchetti, G Greub

Open access · goldAbstract read
In one paragraph

Article in New microbes and new infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. What is the burden of asymptomatic coronavirus infections?New microbes and new infections · 2023
    Article
  8. COVID-19 Rapid Antigen Tests: Bibliometric Analysis of the Scientific Literature.International journal of environmental research and public health · 2022
    Article
  9. Article
  10. Clinical assessment of SARS-CoV-2 antigen rapid detection compared with RT-PCR assay for emerging variants at a high-throughput community testing site in Taiwan.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  11. Article
  12. Clinical Performance of Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection in the Emergency Department and Community: A Retrospective Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Article
  13. Article
  14. Article
  15. The importance of disease prevalence in clinical decision making: a real practice study on COVID-19 antigen test in Curacao.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

G CaruanaInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Switzerland.
L-L LebrunPatients Safety Program, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
O AebischerPatients Safety Program, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
O OpotaInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Switzerland.
L UrbanoPatients Safety Program, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
M de RhamCoVID-19 Task Force Direction, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
O MarchettiPatients Safety Program, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
G GreubInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Switzerland.
Hôpital de Morges · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several reports showed SARS-CoV-2 rapid antigen tests (RATs) performances among COVID-19 symptomatic subjects in outpatient settings during periods of highest incidence of infections and high rates of hospital admissions, but few data are present for asymptomatic patients. We investigated the role of RATs in an emergency department, as a novel screening tool before admission for COVID-19 asymptomatic patients. A total of 116 patients were screened on admission in a 250-bed community hospital in Morges, Switzerland. RAT detected 2/7 RT-PCR-positive patients and delivered two false-positive results. These data suggest the non-fiability of RATs screening in this clinical scenario.

Indexed as

COVID-19 diagnostic testingemergency wardhealth plan implementationrapid antigen testSARS-CoV-2

Identifiers

PMID34007453
PMCPMC8119292
OpenAlexW3161381658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.