Reversible severe ovarian enlargement in an infant with significant insulin resistance.

Lai Lillian, Mikhchi Amir, Ryabets-Lienhard Anna, Geffner Mitchell E, Cheung Clement, Giuffre Danielle

Open access · goldAbstract readCase Reports

In one paragraph

Article in Radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lai LillianDepartment of Radiology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, 4650 Sunset Blvd, Mailstop #81, Los Angeles, CA, USA.

Mikhchi AmirDepartment of Radiology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, 4650 Sunset Blvd, Mailstop #81, Los Angeles, CA, USA.

Ryabets-Lienhard AnnaDivision of Endocrinology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

Geffner Mitchell EDivision of Endocrinology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

Cheung ClementDivision of Endocrinology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

Giuffre DanielleDivision of Endocrinology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

Children's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extent, severity, and radiological findings of ovarian growth in infants with genetic syndromes of insulin resistance have not been fully described. We report a rare case of reversible massive ovarian enlargement in a female infant with a congenital insulin resistance syndrome, likely Rabson-Mendenhall syndrome given the less clinically severe course. The patient presented with neonatal diabetes with hyperinsulinemia and hyperglycemia due to congenital insulin resistance. She developed increasing severe bilateral ovarian enlargement which peaked at 4 months of age, followed by gradual decrease in size of the ovaries following treatment with insulin-sensitizing drugs and improved hyperinsulinemia. The ovarian enlargement is postulated to be secondary to the trophic effects of insulin acting in a gonadotropin-independent mechanism. Hyperinsulinemia in congenital insulin resistance can also result in hypertrophy of other organs. Understanding the pathophysiology behind massive ovarian enlargement in the setting of congenital insulin resistance syndromes can help guide appropriate therapy.

Indexed as

DonohueEnlargementInsulin resistanceOvarianRabson-Mendenhall

Identifiers

PMID34007398

DOI10.1016/j.radcr.2021.03.067

PMCPMC8111256

OpenAlexW3157173087

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.