ReviewGastroenterology research2021
Idiopathic Non-Cirrhotic Portal Hypertension and Porto-Sinusoidal Vascular Disease: Review of Current Data.
Review in Gastroenterology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Overview of Non-Cirrhotic Portal Hypertension in Pediatric Patients.Journal of clinical medicine · 2026Review
- Immunological characteristics of calmodulin-related genes in hepatocellular carcinoma and their potential for prognostic prediction and diagnostic applications.Journal of gastrointestinal oncology · 2026Article
- Liver stiffness measured by transient elastography is associated with hepatic Fibrosis in children with portal vein thrombosis: a retrospective cross-sectional study.Frontiers in pediatrics · 2026Article
- The relationship between hepatic steatosis index and hypertension: NHANES 2011-2018.BMC cardiovascular disorders · 2025Article
- Porto-Sinusoidal Vascular Disease and Downhill Varices: Separate Clinical Entities?GE Portuguese journal of gastroenterology · 2025Article
- The potential roles of gut microbiome in porto-sinusoidal vascular disease: an under-researched crossroad.Frontiers in microbiology · 2025Review
- Porto Sinusoidal Vascular Disorder: A Case Report.International medical case reports journal · 2025Article
- Letter to the Editor: "Liver stiffness by two‑dimensional shear wave elastography for screening high‑risk varices in patients with compensated advanced chronic liver disease".European radiology · 2024Article
- Porto-Sinusoidal Vascular Disease: A New Nomenclature Different from Idiopathic Non-Cirrhotic Portal Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- Link between persistent, unexplained gamma-glutamyltransferase elevation and porto-sinusoidal vascular disorder.JHEP reports : innovation in hepatology · 2024Article
- Navigating Complex Challenges: Preoperative Assessment and Surgical Strategies for Liver Resection in Patients with Fibrosis or Cirrhosis.Biomedicines · 2024Review
- Evaluation of the histologic and immunohistochemical (CD34, glutamine synthetase) findings in idiopathic non-cirrhotic portal hypertension (INCPH).Hepatology international · 2024Article
- A Rare Case of Portal Hypertension and Ascites Following Intrauterine Fetal Death: A Case Report.Cureus · 2024Article
- Outcomes of Proximal Spleno-Renal Shunt Operations for Idiopathic Portal Hypertension in Tertiary Hospital in the Sub-Sahara.International medical case reports journal · 2024Article
- Management of refractory rectal variceal bleed using computed tomography.Bioinformation · 2024Article
- Porto-sinusoidal vascular disease: a new definition of an old clinical entity.Clinical and experimental hepatology · 2023Review
- Updates in noncirrhotic portal hypertension.Clinical liver disease · 2023Article
- CaMolecules (Basel, Switzerland) · 2023Review
- A Case of Porto-Sinusoidal Vascular Disease.European journal of case reports in internal medicine · 2023Article
- Interventional Management of Portal Hypertension in Cancer Patients.Current oncology reports · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic non-cirrhotic portal hypertension (INCPH) is a clinicopathologic disease entity characterized by the presence of clinical signs and symptoms of portal hypertension (PH) in the absence of liver cirrhosis or known risk factors accountable for PH. Multiple hematologic, immune-related, infectious, hereditary and metabolic risk factors have been associated with this disorder. Still, the exact etiopathogenesis is largely unknown. The recently proposed porto-sinusoidal vascular disease (PSVD) scheme broadens the spectrum of the disease by also including patients without clinical PH who are found to have similar histopathologic findings on core liver biopsies. Three histomorphologic lesions have been identified as specific for PSVD to include obliterative portal venopathy, nodular regenerative hyperplasia and incomplete septal cirrhosis/fibrosis. However, these findings are often subtle, under-recognized and subjective with low interobserver agreement among pathologists. Additionally, the natural history of the subclinical forms of the disease remains unexplored. The clinical course is more favorable compared to cirrhosis patients, especially in the absence of clinical PH or liver dysfunction. There are no universally accepted guidelines in regard to diagnosis and treatment of INCPH/PSVD. Hence, this review emphasizes the need to raise awareness of this entity by highlighting its complex pathophysiology and clinicopathologic associations. Lastly, formulation of standardized diagnostic criteria with clinical validation is necessary to avoid misclassifying vascular diseases of the liver and to develop and implement targeted therapeutic strategies.
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