ArticleExperimental and therapeutic medicine2021
Chrysoeriol ameliorates COX-2 expression through NF-κB, AP-1 and MAPK regulation via the TLR4/MyD88 signaling pathway in LPS-stimulated murine macrophages.
Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways.Redox report : communications in free radical research · 2026Review
- Effects of plant flavonoids and selenium on pancreatic hormones and glucose homeostasis in autoimmune thyroiditis.Experimental animals · 2026Article
- Chrysoeriol Alleviates Psoriasis Inflammation and Keratinocyte Hyperproliferation Possibly Through Inhibiting AKT/NF-κB Signaling Activation.Journal of inflammation research · 2026Article
- Elucidating the Mechanisms of Chrysanthemum Action on Atopic Dermatitis via Network Pharmacology and Machine Learning.International journal of molecular sciences · 2025Article
- Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer.Heliyon · 2025Review
- Anti-inflammatory effects of Frondanol, a nutraceutical extract fromFrontiers in pharmacology · 2025Article
- Integrating 16S rRNA Sequencing, Microflora Metabolism, and Network Pharmacology to Investigate the Mechanism of SBL in Alleviating HDM-Induced Allergic Rhinitis.International journal of molecular sciences · 2024Article
- Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring.International journal of molecular sciences · 2024Review
- Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look.Frontiers in immunology · 2024Review
- Thrombin-Induced COX-2 Expression and PGEInternational journal of molecular sciences · 2023Article
- Ethnobotany, phytochemistry and pharmacological properties of Fagopyri Dibotryis Rhizoma: A review.Frontiers in pharmacology · 2023Review
- An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration.JOR spine · 2022Review
- Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin.Antioxidants (Basel, Switzerland) · 2022Article
- Health Benefits and Pharmacological Aspects of Chrysoeriol.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Novel Perceptions on Chemical Profile and Biopharmaceutical Properties ofPlants (Basel, Switzerland) · 2022Article
- Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review.Frontiers in cell and developmental biology · 2022Review
- Chlorogenic Acid as a Positive Regulator in LPS-PG-Induced Inflammation via TLR4/MyD88-Mediated NF-Mediators of inflammation · 2022Article
- TCMIP v2.0 Powers the Identification of Chemical Constituents Available in Xinglou Chengqi Decoction and the Exploration of Pharmacological Mechanisms Acting on Stroke Complicated With Tanre Fushi Syndrome.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chrysoeriol is a flavonoid that has diverse biological properties, including antioxidation, anti-inflammation, chemoprevention and immunomodulation. Despite its reported anti-inflammatory activity, the exact underlying molecular mechanism has not yet been elucidated. In the current study, the anti-inflammatory mechanism of chrysoeriol involving lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) and its upstream signaling molecules was investigated in RAW 264.7 cells. The mechanism was evaluated via ELISA and western blotting assays. Chrysoeriol significantly inhibited LPS-induced prostaglandin E
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.