Evidence map›Paper›PMID 34007186›Full record

ArticleJournal of asthma and allergy2021

Overcoming Barriers to the Effective Management of Severe Asthma in Italy.

Pierluigi Paggiaro, Simona Barbaglia, Stefano Centanni, Davide Croce, Enrico Desideri, Saffi Giustini, Claudio Micheletto, Antonino Musarra, Nicola Scichilone, Ugo Trama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of asthma and allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 1 country.

Pierluigi PaggiaroDepartment of Surgery, Medicine, Molecular Biology, and Critical Care, University of Pisa, Pisa, Italy.
Simona BarbagliaAssociazione Nazionale Pazienti "Respiriamo Insieme", Padova, Italy.
Stefano CentanniDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Davide CroceCenter for Health Economics, Social and Health Care Management, LIUC-Università Cattaneo, Castellanza, Italy.ORCID 0000-0002-9472-3431
Enrico DesideriFondazione Innovazione e Sicurezza in Sanità, Rome, Italy.
Saffi GiustiniItalian General Practitioners' Association "SIMG", Florence, Italy.
Claudio MichelettoCardio-Thoracic Department, Respiratory Unit, Integrated University Hospital, Verona, Italy.
Antonino MusarraAllergy Unit, National Healthcare System, Reggio Calabria, Italy.
Nicola ScichiloneBiomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy.ORCID 0000-0001-6400-6573
Ugo TramaDirigente UOD 06 Politica del Farmaco e Dispositivi, Naples, Italy.
Maria Teresa ZeddaItalian General Practitioners' Association "SIMG", Florence, Italy.
Giorgio Walter CanonicaPersonalized Medicine Asthma & Allergy Clinic, Humanitas University and Research Hospital-IRCCS, Milan, Italy.
ANT Foundation Italy Onlus · ITFondazione Roma · ITHumanitas University · ITSocietà Italiana di Medicina Generale · ITUniversity Carlo Cattaneo · ITUniversity of Cagliari · ITUniversity of Milan · ITUniversity of Palermo · ITUniversity of Pisa · ITUniversity of Reggio Calabria · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeople with severe asthma (SA) often have poor disease control and quality of life, and are at high risk of exacerbations, lung function decline and asthma-related death. The present expert opinion article aimed to identify unmet needs in the management of SA in Italy, and propose possible solutions to address these needs.

methodsAt five multidisciplinary events in Italy, attendees identified factors that interfered with the effective management of SA and suggested how these barriers could be overcome. A core group of 12 Italian experts (pulmonologists, general practitioners, allergists, payers and patients) identified the main issues and proposed possible solutions based on the results from the meetings and relevant articles from the literature. RESULTS AND

conclusionsWe reviewed the gap between real-world practice and guidelines, oral corticosteroid overuse, SA-related mortality, and barriers to effective SA treatment. Common themes were lack of awareness about SA among both patients and clinicians, and lack of networking/information exchange between those involved in the treatment of SA. Participants agreed on the need to implement patient education and create multidisciplinary groups of specialists to improve SA management through multidisciplinary educational initiatives, meetings with local experts, development of a flow chart for referral/connection with local experts and specialized centers. Clinical instruments that might help specialists improve SA management included referral networks, integrated care pathways, phenotyping and treatment algorithms, exacerbation tracking, and examination of electronic medical records for patients with uncontrolled asthma. The following actions need to be implemented in Italy: i) maximize the use of advanced therapies, eg, biologics; ii) increase/improve education for physicians and patients; iii) improve multidisciplinary communication and care coordination; iv) introduce regional and local protocols for SA diagnosis and treatment; and v) change the structure of healthcare services to reduce specialist waiting times and facilitate access to biologic therapies.

Indexed as

biologic therapyexpert opinionoral corticosteroidssevere asthmaunmet needs

Identifiers

PMID34007186
PMCPMC8121981
OpenAlexW3162315550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.