ArticleNature plants2021
A general non-self response as part of plant immunity.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tryptophan metabolism and plant health: mechanisms of action and application prospects.Frontiers in plant science · 2026Pooled it
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- From the leaf to the gut and back again: using synthetic bacterial communities to trace the fate and influence of phyllosphere bacteria in an Arabidopsis-Pieris brassicae system.Environmental microbiome · 2026Article
- Metabolic feedbacks drive population dynamics and can lead to oscillations among leaf bacteria.Nature communications · 2026Article
- Specialized Metabolic Reprogramming in Plant Immunity: Biosynthetic Networks, Spatiotemporal Regulation, and Quantitative Defense.Plants (Basel, Switzerland) · 2026Review
- Cell-type-specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves.The New phytologist · 2026Article
- eMZed 3: flexible and interactive development of scalable LC-MS/MS data analysis workflows in python.Bioinformatics advances · 2026Article
- Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions.Nature communications · 2025Article
- Endophytic commensal bacteria capitalize on the AvrPto-FER pathway to enhance proliferation during early stages of pathogen invasion.The ISME journal · 2025Article
- Plant microbiota feedbacks through dose-responsive expression of general non-self response genes.Nature plants · 2025Article
- A cross-systems primer for synthetic microbial communities.Nature microbiology · 2024Review
- Toward Ecologically Relevant Genetics of Interactions Between Host Plants and Plant Growth-Promoting Bacteria.Advanced genetics (Hoboken, N.J.) · 2024Article
- Spatial metatranscriptomics resolves host-bacteria-fungi interactomes.Nature biotechnology · 2024Article
- Nonpathogenic leaf-colonizing bacteria elicit pathogen-like responses in a colonization density-dependent manner.Plant-environment interactions (Hoboken, N.J.) · 2024Article
- MAPK Cascades in Plant Microbiota Structure and Functioning.Journal of microbiology (Seoul, Korea) · 2024Review
- Unraveling plant-microbe interactions: can integrated omics approaches offer concrete answers?Journal of experimental botany · 2024Article
- Microbiome homeostasis on rice leaves is regulated by a precursor molecule of lignin biosynthesis.Nature communications · 2024Article
- Identifying microbiota community patterns important for plant protection using synthetic communities and machine learning.Nature communications · 2023Article
- The seed microbiomes of staple food crops.Microbial biotechnology · 2023Review
- Phyllosphere Microbiome in Plant Health and Disease.Plants (Basel, Switzerland) · 2023Review
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11 authors.
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Abstract
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metabolic adaptations to bacterial encounters. We identified a molecular response, which we termed the general non-self response (GNSR) that involves the expression of a core set of 24 genes. The GNSR genes are not only consistently induced by the presence of most strains, they also comprise the most differentially regulated genes across treatments and are predictive of a hierarchical transcriptional reprogramming beyond the GNSR. Using a complementary untargeted metabolomics approach we link the GNSR to the tryptophan-derived secondary metabolism, highlighting the importance of small molecules in plant-microbe interactions. We demonstrate that several of the GNSR genes are required for resistance against the bacterial pathogen Pseudomonas syringae. Our results suggest that the GNSR constitutes a defence adaptation strategy that is consistently elicited by diverse strains from various phyla, contributes to host protection and involves secondary metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.