ArticlePediatric research2021
Renal tissue oxygenation after caffeine administration in preterm neonates.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Caffeine and preterm infants: multiorgan effects and therapeutic creep: scope to optimise dose and timing.Pediatric research · 2026Review
- A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Acute Effects of Aminophylline Effects on Hemodynamic Parameters and Fluid Balance in Pediatric Cardiac Intensive Care Patients: Machine Learning Insights Using High Fidelity Data.Pediatric cardiology · 2025Article
- The incidence of acute kidney injury in very-low-birth-weight infants treated early with caffeine.Pediatric nephrology (Berlin, Germany) · 2025Article
- Decreased Intraoperative Renal Tissue Oxygenation after Cardiopulmonary Bypass Predicts Cardiac Surgery-Associated Acute Kidney Injury in Neonates.Children (Basel, Switzerland) · 2024Article
- The Babyccino: The Role of Caffeine in the Prevention of Acute Kidney Injury in Neonates-A Literature Review.Healthcare (Basel, Switzerland) · 2024Review
- Caffeine intake improves the cognitive performance of patients with chronic kidney disease.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine has been associated with reduced rates of acute kidney injury (AKI) in preterm neonates. The effect of caffeine on preterm neonatal renal regional saturation of oxygen (RrSO
methodsRrSO
resultsOf 35 eligible neonates, 31 (median gestational age 28.4 weeks) received 156 caffeine doses (median 8 mg/kg). Analysis of combined doses showed no significant changes in RrSO
conclusionsMaintenance caffeine dosing increased RrSO IMPACT: Caffeine administration is associated with increased renal tissue oxygenation in preterm neonates with low baseline values under 40%. The most significant renal tissue oxygenation changes occur in the first 3 h after IV caffeine administration. With recent studies suggesting low RrSO
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Registered trials
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