Evidence map›Paper›PMID 34006971›Full record

ArticleScientific reports2021

X-chromosome variants are associated with aldosterone producing adenomas.

Ravi Kumar Dutta, Malin Larsson, Thomas Arnesen, Anette Heie, Martin Walz, Piero Alesina, Oliver Gimm, Peter Söderkvist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ravi Kumar DuttaDivision of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, 58183, Linköping, Sweden. ravi.kumar.dutta@liu.se.
Malin LarssonScience for Life Laboratory, Department of Physics, Chemistry and Biology, Linköping University, 58183, Linköping, Sweden.
Thomas ArnesenDepartment of Surgery, Haukeland University Hospital, Bergen, Norway.
Anette HeieDepartment of Surgery, Haukeland University Hospital, Bergen, Norway.
Martin WalzKlinik Für Chirurgie and Zentrum Für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Essen, Germany.
Piero AlesinaKlinik Für Chirurgie and Zentrum Für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Essen, Germany.
Oliver Gimm *Department of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, 58183, Linköping, Sweden.
Peter Söderkvist *Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, 58183, Linköping, Sweden.
Linköping University · SEHaukeland University Hospital · NOKliniken Essen-Mitte · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism (PA) and are characterized by constitutively producing aldosterone, which leads to hypertension. Several mutations have been identified in ion channels or ion channel-associated genes that result in APAs. To date, no studies have used a genome-wide association study (GWAS) approach to search for predisposing loci for APAs. Thus, we investigated Scandinavian APA cases (n = 35) and Swedish controls (n = 60) in a GWAS and discovered a susceptibility locus on chromosome Xq13.3 (rs2224095, OR = 7.9, 95% CI = 2.8-22.4, P = 1 × 10

Indexed as

Chromosomes, Human, XAdenomaAldosteroneCarrier ProteinsCase-Control StudiesCohort StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGerm-Line MutationHumansMaleMiddle AgedNerve Tissue ProteinsNuclear ProteinsPolymorphism, Single NucleotideQuantitative Trait LociAldosteroneCarrier ProteinsMAGEE1 protein, humanNerve Tissue ProteinsNuclear Proteins

Identifiers

PMID34006971
PMCPMC8131628
OpenAlexW3162767235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.