Evidence map›Paper›PMID 34006967›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2022

Effect of enteral zinc supplementation on growth and neurodevelopment of preterm infants: a systematic review and meta-analysis.

Belal Alshaikh, Moaaz Abo Zeed, Kamran Yusuf, Madhusudan Guin, Tanis Fenton

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Tracing Zinc's Role in Preterm Infants' Health: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2024
    Review
  7. Rethinking Zinc-Do We Need Catch-Up Evidence or Just Catch-Up Care?Advances in nutrition (Bethesda, Md.) · 2024
    Article
  8. Article
  9. Review
  10. Neurodevelopmental outcomes of preterm infants.Clinical and experimental pediatrics · 2023
    Article
  11. Does enteral zinc supplementation affect growth and neurodevelopment in preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Belal AlshaikhNeonatal Nutrition and Gastroenterology Program, University of Calgary, Calgary, AB, Canada. balshaik@ucalgary.ca.ORCID 0000-0002-6080-6888
Moaaz Abo ZeedMcMaster University, Hamilton, AB, Canada.ORCID 0000-0001-5749-8901
Kamran YusufNeonatal Nutrition and Gastroenterology Program, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-5270-5326
Madhusudan GuinNeonatal Nutrition and Gastroenterology Program, University of Calgary, Calgary, AB, Canada.
Tanis FentonCommunity Health Sciences, Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-9585-9149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate effect of enteral zinc supplementation on growth and neurodevelopmental outcomes of preterm infants. STUDY

designA systematic review and meta-analysis of randomized-controlled trials (RCTs) examining growth and neurodevelopmental outcomes after zinc supplementation in preterm infants.

resultsOf eight RCTs involving 742 infants included, seven reported growth anthropometrics at 3-6 months corrected age (CA) and two reported neurodevelopmental outcomes at 6-12 months CA. Zinc supplementation was associated with increased weight z-score (weighted mean difference (WMD) = 0.50; 95% CI 0.23-0.76, heterogeneity I

conclusionZinc supplementation may enhance weight gain and linear growth in preterm infants. There is a lack of data about relationship between zinc supplementation and neurodevelopment.

Indexed as

Infant, PrematureZincDietary SupplementsHumansInfantInfant, NewbornWeight GainZinc

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.