ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2021
Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pooled it
- Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature.Frontiers in medicine · 2022Pooled it
- Rethinking preeclampsia: six paradigm shifts in placental pathophysiology for maternal-foetal medicine.Frontiers in medicine · 2026Review
- Chronic Histiocytic Intervillositis: From Microscopic Placental Pathology to Clinical Impact-Case Series.Case reports in pathology · 2026Article
- Alterations of placental HERV expression as a result of gestational COVID-19 disease.Frontiers in microbiology · 2026Article
- Review
- Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome.Diseases (Basel, Switzerland) · 2024Review
- Acute placental insufficiency two weeks after an asymptomatic COVID-19 maternal infection: the deleterious effects of the SARS-CoV-2 placentitis.Archives of gynecology and obstetrics · 2024Article
- SARS-CoV-2 Infection in Late Pregnancy and Childbirth from the Perspective of Perinatal Pathology.Journal of developmental biology · 2023Review
- A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts.Nature cell biology · 2023Article
- The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis.Obstetrics & gynecology science · 2023Article
- Placental pathology in sudden intrauterine death (SIUD) in SARS-CoV-2-positive oligosymptomatic women.Archives of gynecology and obstetrics · 2023Article
- Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.Stem cells and development · 2023Article
- The Histopathological "Placentitis Triad" Is Specific for SARS-CoV-2 Infection, and Its Acute Presentation Can Be Associated with Poor Fetal Outcome.Life (Basel, Switzerland) · 2023Article
- Article
- Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- The Significance of COVID-19 Diseases in Lipid Metabolism Pregnancy Women and Newborns.International journal of molecular sciences · 2022Review
- SARS-CoV-2 can infect human embryos.Scientific reports · 2022Article
- Absence of SARS-CoV-2 Spike glycoprotein expression in placentas from individuals after mRNA SARS-CoV-2 vaccination.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Restriction of SARS-CoV-2 replication in the human placenta.Placenta · 2022Article
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific. However, the identification of the placental lesions due to SARS-CoV-2 infection would be a significant advance in order to improve the management of these pregnancies and to identify the mechanisms involved in a possible vertical transmission. The pathological findings in placentas delivered from 198 SARS-CoV-2-positive pregnant women were investigated for the presence of lesions associated with placental SARS-CoV-2 infection. SARS-CoV-2 infection was investigated in placental tissues through immunohistochemistry, and positive cases were further confirmed by in situ hybridization. SARS-CoV-2 infection was also investigated by RT-PCR in 33 cases, including all the immunohistochemically positive cases. Nine cases were SARS-CoV-2-positive by immunohistochemistry, in situ hybridization, and RT-PCR. These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition. Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death. Two of the stillborn fetuses showed some evidence of SARS-CoV-2 positivity. The remaining 189 placentas did not show similar lesions. The strong association between trophoblastic damage and placenta SARS-CoV-2 infection suggests that this lesion is a specific marker of SARS-CoV-2 infection in placenta. Diffuse trophoblastic damage, massively affecting chorionic villous tissue, can result in fetal death associated with COVID-19 disease.
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