ArticleNature communications2021
Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions.Nature human behaviour · 2024Pooled it
- Oxytocin receptor signaling in the dorsal lateral septum is essential for social transmission of food preference in mice.PLoS biology · 2026Article
- Article
- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
- Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex.Neurobiology of stress · 2026Article
- Ventromedial hypothalamus IL-6 signaling mediates the excessive aggressive behavior induced by late-gestational sleep deprivation in male mice.Behavioral and brain functions : BBF · 2026Article
- Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.Neuroscience bulletin · 2026Article
- Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner.Translational psychiatry · 2026Article
- Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male mice.Journal of neuroendocrinology · 2026Article
- SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons.Communications biology · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Sex differences in the neural circuitry of aggression.bioRxiv : the preprint server for biology · 2025Article
- Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner.Communications biology · 2025Article
- Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.Translational psychiatry · 2025Article
- Medial preoptic CCKAR mediates anxiety and aggression induced by chronic emotional stress in male mice.National science review · 2025Article
- Reunion with a peer partner reduces PVN oxytocin neuron immunoreactivity in socially selective voles.Scientific reports · 2025Article
- Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit.Nature communications · 2025Article
- Sex differences in structural and receptor mRNA expression in the ventral anterior cingulate cortex and a potential role of perineuronal nets in monogamous pair bond establishment (Peromyscus californicus).Biology of sex differences · 2025Article
- Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3BNature communications · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
14 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and arginine vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialysis approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), is required for aggression in female rats. Accordingly, increased activity of putative OXT receptor-positive neurons in the vLS, and decreased activity of putative AVP receptor-positive neurons in the dLS, are likely to underly aggression in female rats. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data suggest a model showing that septal release of OXT and AVP differentially affects aggression in females by modulating the inhibitory tone within LS sub-networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.