Evidence map›Paper›PMID 34006658›Full record

ArticlemBio2021

Genetic Network Architecture and Environmental Cues Drive Spatial Organization of Phenotypic Division of Labor in Streptomyces coelicolor.

Vineetha M Zacharia, Yein Ra, Catherine Sue, Elizabeth Alcala, Jewel N Reaso, Steven E Ruzin, Matthew F Traxler

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Factors that influence the caste ratio in a bacterial division of labour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cryptic specialized metabolites driveProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Ecological drivers of division of labour in Streptomyces.Current opinion in microbiology · 2022
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vineetha M ZachariaDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.ORCID 0000-0003-4311-9119
Yein RaDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Catherine SueDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Elizabeth AlcalaDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Jewel N ReasoDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Steven E RuzinDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Matthew F TraxlerDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA mtrax@berkeley.edu.ORCID 0000-0001-8430-595X
University of California, Berkeley · US

Funding

Connecting specialized metabolism to social cues in actinomycete bacteriaR35GM128849 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Matthew F Traxler · 2018 to 2026
$3.3M
NIGMS NIH HHS R35 GM128849
6 · The paper itself

Abstract

A number of bacteria are known to differentiate into cells with distinct phenotypic traits during processes such as biofilm formation or the development of reproductive structures. These cell types, by virtue of their specialized functions, embody a division of labor. However, how bacteria build spatial patterns of differentiated cells is not well understood. Here, we examine the factors that drive spatial patterns in divisions of labor in colonies of

Indexed as

EnvironmentGene Expression Regulation, BacterialGene Regulatory NetworksPhenotypeBacterial ProteinsSpores, BacterialStreptomyces coelicolorBacterial Proteinschemical gradientsdevelopmentdivision of laborglobal regulatory networksmulticellular bacteriumnatural productsregulatory networkssiderophores

Identifiers

PMID34006658
PMCPMC8262882
OpenAlexW3163620742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.