Evidence map›Paper›PMID 34006653›Full record

ArticlemBio2021

Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila.

Bradford Becken, Lauren Davey, Dustin R Middleton, Katherine D Mueller, Agastya Sharma, Zachary C Holmes, Eric Dallow, Brenna Remick, Gregory M Barton, Lawrence A David and 4 more

Abstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. mBio · 2026
    Article
  8. Therapeutic efficacy of Jichuan decoction in slow-transit constipation: focus on gut microbiota modulation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Article
  9. Microbe on the move:Journal of bacteriology · 2026
    Review
  10. Biomolecules · 2026
    Review
  11. Article
  12. Frontiers in microbiology · 2026
    Review
  13. Review
  14. Review
  15. Article
  16. International journal of molecular sciences · 2025
    Review
  17. Review
  18. The Biology ofAnnual review of microbiology · 2025
    Review
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bradford Becken *Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Lauren Davey *Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Dustin R MiddletonDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Katherine D MuellerDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Agastya SharmaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Zachary C HolmesDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Eric DallowDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Brenna RemickDivision of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Gregory M BartonDivision of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Lawrence A DavidDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-3570-4767
Jessica R McCannDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Sarah C ArmstrongDepartment of Pediatrics, Duke University Hospital, Durham, North Carolina, USA.
Per MalkusDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Raphael H ValdiviaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA raphael.valdivia@duke.edu.ORCID 0000-0003-0961-073X

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeuticsR24DK110492 · NIDDK · DUKE UNIVERSITY · PI RAWLS, JOHN F, SEED, PATRICK C. · 2016 to 2020
$7.2M
DUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6M
Mechanisms of mucin binding and acquisition by AkkermansiaR01AI142376 · NIAID · DUKE UNIVERSITY · PI Raphael H Valdivia · 2018 to 2026
$2.9M
The impact of genetic diversity among Akkermansia strains on the effectivenes of immune checkpoint inhibitors in cancer immunotherapiesR21CA249243 · NCI · DUKE UNIVERSITY · PI HE, YOU-WEN, VALDIVIA, RAPHAEL H · 2020 to 2021
$414k
NCI NIH HHS R21 CA249243NIAID NIH HHS R01 AI142376NICHD NIH HHS K12 HD000850NIDDK NIH HHS R24 DK110492NIDDK NIH HHS T32 DK007568
6 · The paper itself

Abstract

The mucophilic anaerobic bacterium

Indexed as

Genetic VariationGenotypePhenotypeAkkermansiaAnimalsCohort StudiesFemaleGastrointestinal MicrobiomeHT29 CellsHumansMiceMice, Inbred C57BLPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNARNA, Ribosomal, 16Sadolescent obesityassimilatory sulfur reduction (ASR)comparative genomicsmicrobiomemucinphylogenetic analysisphylogroupsVerrucomicrobia

Identifiers

PMID34006653
PMCPMC8262928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.