Evidence map›Paper›PMID 34006652›Full record

ArticlemBio2021

Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System.

Anna-Lisa E Lawrence, Basel H Abuaita, Ryan P Berger, David R Hill, Sha Huang, Veda K Yadagiri, Brooke Bons, Courtney Fields, Christiane E Wobus, Jason R Spence and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Esculetin Combats Multidrug-ResistantAntioxidants (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Frontiers in veterinary science · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Anna-Lisa E Lawrence *Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Basel H Abuaita *Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Ryan P BergerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
David R HillDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Sha HuangDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Veda K YadagiriDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Brooke BonsDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Courtney FieldsDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-5286-0924
Jason R SpenceDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Vincent B YoungDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3687-2364
Mary X O'RiordanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA oriordan@umich.edu.ORCID 0000-0001-6014-4637
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Stem Cell Differentiation CoreU19AI116482 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOBUS, CHRISTIANE · 2015 to 2019
$6.4M
NCI NIH HHS P30 CA046592NIAID NIH HHS T32 AI007528NIAID NIH HHS U19 AI116482NIDDK NIH HHS P30 DK034933
6 · The paper itself

Abstract

The intestinal epithelium is a primary interface for engagement of the host response by foodborne pathogens, like

Indexed as

Gene Expression ProfilingBacterial ProteinsCell LineEnterocytesGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansIntestinal MucosaIntestinesMembrane ProteinsOrganoidsSalmonella typhimuriumSerogroupVirulence FactorsBacterial ProteinsMembrane ProteinsSpi1 protein, SalmonellaSPI-2 protein, SalmonellaVirulence Factorsenteric infectionhost responseorganoid

Identifiers

PMID34006652
PMCPMC8262845
OpenAlexW3162616609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.