Evidence map›Paper›PMID 34006643›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Cell lineage tracing links ERα loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype.

Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B Lanz, Bert W O'Malley, Jianming Xu

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Advances in Immunocompetent Mouse and Rat Models.Cold Spring Harbor perspectives in medicine · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. DMNet: Dual-Stream Marker Guided Deep Network for Dense Cell Segmentation and Lineage Tracking.... IEEE International Conference on Computer Vision workshops. IEEE International Conference on Computer Vision · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yunfeng DingDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-6592-1159
Yonghong LiuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-2609-7720
Dong-Kee LeeDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9063-9048
Zhangwei TongDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Xiaobin YuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9727-351X
Yi LiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9976-518X
Yong XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Rainer B LanzDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-1713-8527
Bert W O'MalleyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; berto@bcm.edu jxu@bcm.edu.ORCID 0000-0003-3332-1399
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; berto@bcm.edu jxu@bcm.edu.ORCID 0000-0002-8208-9162
Baylor College of Medicine · US

Funding

NCOA6, A Novel Tumor Suppressor of Endometrial CancerR01CA193455 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2016 to 2021
$1.9M
NCI NIH HHS R01 CA193455
6 · The paper itself

Abstract

HER2-positive (HER2

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCell LineageCell Line, TumorCell ProliferationCell Transformation, NeoplasticErb-b2 Receptor Tyrosine KinasesEstrogen Receptor alphaFemaleGATA3 Transcription FactorHepatocyte Nuclear Factor 3-alphaHumansLung NeoplasmsMiceERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesESR1 protein, humanEstrogen Receptor alphaFOXA1 protein, humanGATA3 protein, humanGATA3 Transcription FactorHepatocyte Nuclear Factor 3-alphaMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3cancer cell origincell lineage tracingestrogen receptorHER2+ breast cancermetastasis

Identifiers

PMID34006643
PMCPMC8166171
OpenAlexW3160434710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.