Evidence map›Paper›PMID 34006570›Full record

ArticleGenome research2021

CTCF looping is established during gastrulation in medaka embryos.

Ryohei Nakamura, Yuichi Motai, Masahiko Kumagai, Candice L Wike, Haruyo Nishiyama, Yoichiro Nakatani, Neva C Durand, Kaori Kondo, Takashi Kondo, Tatsuya Tsukahara and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 61 citations in OpenAlex.

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  11. Acquisition and Analysis Methods for Hi-C Data from Medaka Early Embryos.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Ryohei Nakamura *Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033 Japan.ORCID 0000-0002-7812-8034
Yuichi Motai *Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan.
Masahiko KumagaiAdvanced Analysis Center, National Agriculture and Food Research Organization, Tsukuba, Ibaraki 305-8602, Japan.
Candice L WikeHoward Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Haruyo NishiyamaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033 Japan.
Yoichiro NakataniDepartment of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0001-7604-0242
Neva C DurandThe Center for Genome Architecture, Baylor College of Medicine, Houston, Texas 77030, USA.
Kaori KondoRIKEN-IMS, Laboratory for Developmental Genetics, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Takashi KondoRIKEN-IMS, Laboratory for Developmental Genetics, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Tatsuya TsukaharaDepartment of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Atsuko ShimadaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033 Japan.
Bradley R CairnsHoward Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Erez Lieberman AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, Texas 77030, USA.
Shinichi MorishitaDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan.
Hiroyuki TakedaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033 Japan.
The University of Tokyo · JPBroad Institute · USHoward Hughes Medical Institute · USRIKEN Center for Integrative Medical Sciences · JPHarvard University · USNational Agriculture and Food Research Organization · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromatin looping plays an important role in genome regulation. However, because ChIP-seq and loop-resolution Hi-C (DNA-DNA proximity ligation) are extremely challenging in mammalian early embryos, the developmental stage at which cohesin-mediated loops form remains unknown. Here, we study early development in medaka (the Japanese killifish,

Indexed as

OryziasAnimalsCCCTC-Binding FactorCell Cycle ProteinsChromatinGastrulationMiceZebrafishCCCTC-Binding FactorCell Cycle ProteinsChromatin

Identifiers

PMID34006570
PMCPMC8168583
OpenAlexW3162873709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.