Evidence map›Paper›PMID 34006506›Full record

ArticleBritish journal of sports medicine2021

Joint association between accelerometry-measured daily combination of time spent in physical activity, sedentary behaviour and sleep and all-cause mortality: a pooled analysis of six prospective cohorts using compositional analysis.

Sebastien Chastin, Duncan McGregor, Javier Palarea-Albaladejo, Keith M Diaz, Maria Hagströmer, Pedro Curi Hallal, Vincent T van Hees, Steven Hooker, Virginia J Howard, I-Min Lee and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in British journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883591 (Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty), which is not on this map. Cited by 75 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06883591 completednot on this mapstarted 2025, after this paper: background citation

Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty: an Observational Follow-up Study 15 Years After Surgery.

TypeobservationalSponsorRijnstate HospitalRan2025 to 2026Enrolled32ConditionsTotal Hip Arthroplasty (THA), Accelerometers, Resurfacing Hip Arthroplasty
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis.The international journal of behavioral nutrition and physical activity · 2026
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sebastien Chastin *School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK Sebastien.Chastin@gcu.ac.uk.ORCID http://orcid.org/0000-0003-1421-9348
Duncan McGregor *School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Javier Palarea-AlbaladejoBiomathematics and Statistics Scotland, Edinburgh, UK.
Keith M DiazDepartment of Medicine, Columbia University Medical Center, New York, New York, USA.
Maria HagströmerDivision of Physiotherapy, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institute, Stockholm, Sweden.
Pedro Curi HallalFederal University of Pelotas, Pelotas, Brazil.
Vincent T van HeesAccelting, Almere, The Netherlands.
Steven HookerExercise Science and Health Promotion Program, College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.
Virginia J HowardUniversity of Alabama School of Medicine, Birmingham, Alabama, USA.
I-Min LeeDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-1083-6907
Philip von RosenDivision of Physiotherapy, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institute, Stockholm, Sweden.
Séverine SabiaInserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Paris, France.
Eric J ShiromaLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland, USA.
Manasa S YerramallaInserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Paris, France.
Philippa DallSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsR01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARY CUSHMAN, VIRGINIA J. HOWARD · 2001 to 2026
$8.8M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Impact of Physical Activity on Stroke and Cognitive Function in Older AdultsR01NS061846 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HOOKER, STEVEN PAUL · 2008 to 2012
$2.9M
Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Use of accelerometry data for patterns of daily activity in older personsZIAAG006020 · NIA · NATIONAL INSTITUTE ON AGING · PI SHIROMA, ERIC · 2009 to 2021
$2.7M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
British Heart Foundation RG/16/11/32334Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA154647NCI NIH HHS U01 CA182913NCI NIH HHS UM1 CA182913NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIA NIH HHS R01 AG034454NIA NIH HHS R01 AG056477NIDDK NIH HHS P30 DK079626NINDS NIH HHS R01 NS041588NINDS NIH HHS R01 NS061846NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

objectiveTo examine the joint associations of daily time spent in different intensities of physical activity, sedentary behaviour and sleep with all-cause mortality.

methodsFederated pooled analysis of six prospective cohorts with device-measured time spent in different intensities of physical activity, sedentary behaviour and sleep following a standardised compositional Cox regression analysis.

participants130 239 people from general population samples of adults (average age 54 years) from the UK, USA and Sweden. MAIN OUTCOME: All-cause mortality (follow-up 4.3-14.5 years).

resultsStudies using wrist and hip accelerometer provided statistically different results (I

conclusionThis federated analysis shows a joint dose-response association between the daily balance of time spent in physical activity of different intensities and sedentary behaviour with all-cause mortality, while sleep duration does not appear to be significant. The strongest association is with time spent in moderate to vigorous physical activity, but it is modified by the balance of time spent in light physical activity relative to sedentary behaviour.

Indexed as

AccelerometrySedentary BehaviorAdultExerciseHumansMiddle AgedProspective StudiesSleephealthphysical activitysleep

Identifiers

PMID34006506
PMCPMC8543228

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.