Evidence map›Paper›PMID 34006230›Full record

ArticleBMC infectious diseases2021

Predictive factors of viral load high-risk events for virological failure in HIV/AIDS patients receiving long-term antiviral therapy.

Shanfang Qin, Jingzhen Lai, Hong Zhang, Di Wei, Qing Lv, Xue Pan, Lihua Huang, Ke Lan, Zhihao Meng, Hao Liang and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shanfang Qin *Guangxi AIDS Diagnosis and Treatment Quality Control Center, Longtan Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, 545005, Guangxi, China.
Jingzhen Lai *Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Hong ZhangGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Di WeiDepartment of Infectious Diseases, Longtan Hospital of Guangxi Zhuang Autonomous Region, No. 8 Yangjiaoshan Road, Liuzhou, 545005, Guangxi, China.
Qing LvDepartment of Infectious Diseases, Longtan Hospital of Guangxi Zhuang Autonomous Region, No. 8 Yangjiaoshan Road, Liuzhou, 545005, Guangxi, China.
Xue PanGuangxi AIDS Diagnosis and Treatment Quality Control Center, Longtan Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, 545005, Guangxi, China.
Lihua HuangClinical Laboratory, Longtan Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, 545005, Guangxi, China.
Ke LanDepartment of Infectious Diseases, Longtan Hospital of Guangxi Zhuang Autonomous Region, No. 8 Yangjiaoshan Road, Liuzhou, 545005, Guangxi, China.
Zhihao MengDepartment of Infectious Diseases, Longtan Hospital of Guangxi Zhuang Autonomous Region, No. 8 Yangjiaoshan Road, Liuzhou, 545005, Guangxi, China. chimzh@sina.com.
Hao LiangGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, 530021, Guangxi, China. lianghao@gxmu.edu.cn.
Chuanyi NingGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, 530021, Guangxi, China. ningchuanyi@126.com.ORCID http://orcid.org/0000-0002-8748-2780
Guangxi Longtan Hospital · CNGuangxi Medical University · CNGuangxi University · CN

Funding

National Major Science and Technology Projects of China 2017ZX10202101-001-006National Major Science and Technology Projects of China 2018ZX10302104-001National Major Science and Technology Projects of China 2018ZX10715008-002National Natural Science Foundation of China 81760602National Natural Science Foundation of China 81803295Youth Science Foundation of Guangxi Medical University GXMUYSF201827
6 · The paper itself

Abstract

backgroundIn the era of anti-retroviral therapy (ART), the plasma HIV viral load (VL) is an important primary indicator for monitoring the HIV treatment response. To optimize the clinical management of HIV/AIDS patients, we investigated VL high-risk events related to virological failure (VF) and further explored the preventive factors of VL high-risk events.

methodsThe data were derived from China's HIV/AIDS Comprehensive Response Information Management System. HIV infected patients who initiated or received ART in Guangxi between 2003 and 2019 were included. The contributions of VL after 6 months of ART to VF and AIDS-related death were analysed by Kaplan-Meier curves, log-rank tests and Cox regression analyses. Both descriptive analyses and bivariate logistic regression were employed to further explore the preventive factors related to VL high-risk events of VF.

resultsThe cumulative rates of VF in the high low-level viremia group (high LLV) (χ

conclusionsA VL greater than 200 copies/ml is a VL high-risk event for VF. Intervention measurements should be adopted to optimize the surveillance of ART in patients who are single or widowed, who have ART modification, and who use cotrimoxazole during ART.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsChinaFemaleHIV-1HumansIncidenceMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesSurvival RateTreatment FailureViral LoadAnti-Retroviral AgentsAIDSARTHIVViral loadVirological failure

Identifiers

PMID34006230
PMCPMC8130293
OpenAlexW3124307256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.