Evidence map›Paper›PMID 34006192›Full record

ArticleGut microbes

Bioactive small molecules produced by the human gut microbiome modulate

Heidi Pauer, Felipe Lopes Teixeira, Avery V Robinson, Thiago E Parente, Marília A F De Melo, Leandro A Lobo, Regina M C P Domingues, Emma Allen-Vercoe, Rosana B R Ferreira, Luis Caetano M Antunes

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Virulence · 2026
    Article
  3. Microorganisms · 2026
    Article
  4. Postbiotic activity of Akkermansia muciniphila supernatant against antibiotic-resistant Enterococcus faecalis.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  5. Microbes as medicine.Annals of the New York Academy of Sciences · 2024
    Review
  6. Article
  7. Review
  8. Crosstalk between gut microbiota and renal ischemia/reperfusion injury.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Heidi PauerInstituto Nacional de Ciência e Tecnologia de Inovação Em Doenças De Populações Negligenciadas, Centro De Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Felipe Lopes TeixeiraDepartamento de Tecnologia Farmacêutica, Universidade Federal Fluminense, Niterói, Brazil.
Avery V RobinsonDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Canada.
Thiago E ParenteLaboratório de Genômica Funcional e Bioinformática, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0001-7501-726X
Marília A F De MeloLaboratório de Genômica Funcional e Bioinformática, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Leandro A LoboDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio De Janeiro, Rio de Janeiro, Brazil.
Regina M C P DominguesDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio De Janeiro, Rio de Janeiro, Brazil.
Emma Allen-VercoeDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Canada.ORCID 0000-0002-8716-327X
Rosana B R FerreiraDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio De Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-7162-0026
Luis Caetano M AntunesInstituto Nacional de Ciência e Tecnologia de Inovação Em Doenças De Populações Negligenciadas, Centro De Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0003-1686-0788
Universidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BRUniversity of Guelph · CAEscola Nacional de Saúde Pública · BRInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out many specific tasks that benefit the host, including protection against invading pathogens. Within the chemical diversity of the gastrointestinal tract, small molecules likely constitute chemical cues for the communication between the microbiota and pathogens. Therefore, we sought to investigate if molecules produced by the human gut microbiota show biological activity against the human pathogen

Indexed as

Gastrointestinal MicrobiomeMetabolomeAdultBacteriaFecesFemaleGene Expression Regulation, BacterialHumansMicrobial InteractionsPlanktonVibrio choleraeAntivirulenceBioactive small moleculesGut metabolomeMicrobial signalingMotilityVibrio cholerae

Identifiers

PMID34006192
PMCPMC8143261
OpenAlexW3163629225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.