Evidence map›Paper›PMID 34006179›Full record

ArticleRNA biology2021

Xianzhi Lin, Marcos A S Fonseca, Joshua J Breunig, Rosario I Corona, Kate Lawrenson

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xianzhi LinCedars-Sinai Medical Center, Women's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.ORCID 0000-0001-9802-9896
Marcos A S FonsecaCedars-Sinai Medical Center, Women's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.
Joshua J BreunigCedars-Sinai Medical Center, Board of Governors Regenerative Medicine Institute, Los Angeles, CA, USA.ORCID 0000-0002-3735-3390
Rosario I CoronaCedars-Sinai Medical Center, Women's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.ORCID 0000-0003-0470-4446
Kate LawrensonCedars-Sinai Medical Center, Women's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.ORCID 0000-0002-6469-2515
Cedars-Sinai Medical Center · US

Funding

Epidemiology and biology of lncRNAs in ovarian cancerR01CA207456 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GAYTHER, SIMON ANDREW, KANETSKY, PETER A · 2016 to 2020
$4.4M
Common biology underlying pleiotropic breast, prostate and ovarian cancer risk lociR01CA259058 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MATTHEW L FREEDMAN, Simon Andrew Gayther · 2022 to 2026
$2.5M
Functional Analysis of LncRNAs in Epithelial Ovarian CancerR00CA184415 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LAWRENSON, KATE · 2015 to 2017
$720k
Functional Analysis of LncRNAs in Epithelial Ovarian CancerK99CA184415 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LAWRENSON, KATE · 2014 to 2014
$97k
NCI NIH HHS K99 CA184415NCI NIH HHS R00 CA184415NCI NIH HHS R01 CA207456NCI NIH HHS R01 CA259058
6 · The paper itself

Abstract

RNA molecules function as messenger RNAs (mRNAs) that encode proteins and noncoding transcripts that serve as adaptor molecules, structural components, and regulators of genome organization and gene expression. Their function and regulation are largely mediated by RNA binding proteins (RBPs). Here we present RNA proximity labelling (RPL), an RNA-centric method comprising the endonuclease-deficient Type VI CRISPR-Cas protein dCas13b fused to engineered ascorbate peroxidase APEX2. RPL discovers target RNA proximal proteins

Indexed as

Ascorbate PeroxidasesBiotinylationCRISPR-Associated ProteinsCRISPR-Cas SystemsHEK293 CellsHumansPoly ARecombinant Fusion ProteinsRNARNA-Binding ProteinsRNA, Guide, CRISPR-Cas SystemsRNA, Small NuclearStaining and LabelingAscorbate PeroxidasesCRISPR-Associated ProteinsPoly ARecombinant Fusion ProteinsRNARNA-Binding ProteinsRNA, Guide, CRISPR-Cas SystemsRNA, Small NuclearU1 small nuclear RNAengineered soybean ascorbate peroxidase APEX2noncoding RNAs (ncRNAs)poly(A) tailproximity-dependent biotinylationRNA binding proteins (RBPs)RNA-centric methodRNA proximal proteinsRNA proximity labelling (RPL)RRNA–proteininteractionsType VI Crispr-Cas (Cas13)U1 snRNA RBPS

Identifiers

PMID34006179
PMCPMC8648264
OpenAlexW3162048909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.