ArticleThe Australian and New Zealand journal of psychiatry2022
Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum.
Article in The Australian and New Zealand journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Trust learning in the repeated trust game: A meta-analytic study.British journal of psychology (London, England : 1953) · 2026Pooled it
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Relationships between attachment insecurity, beliefs about the self and others, paranoia, and social functioning across the psychosis continuum.The British journal of clinical psychology · 2026Article
- The relationship between mental state decoding and real-world social functioning - An experience sampling investigation.Schizophrenia research. Cognition · 2026Article
- Advancing scientific understanding of the drive to socially engage: from broad constructs to transdiagnostic 'building blocks'.Molecular psychiatry · 2026Review
- Willingness to trust is reduced by loneliness and paranoia.Communications psychology · 2025Article
- A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation.Schizophrenia research. Cognition · 2025Article
- Do interpersonal trust and social avoidance mediate the association between psychotic symptoms and social functioning in chronic schizophrenia patients?Frontiers in psychiatry · 2025Article
- Ecological momentary assessment (EMA) combined with unsupervised machine learning shows sensitivity to identify individuals in potential need for psychiatric assessment.European archives of psychiatry and clinical neuroscience · 2024Article
- Reading the mind in the eyes and cognitive ability in schizophrenia- and autism spectrum disorders.Psychological medicine · 2023Article
- Do loneliness and social exclusion breed paranoia? An experience sampling investigation across the psychosis continuum.Schizophrenia research. Cognition · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Exploring the association between social behaviour, trust, and its neural correlates in first episode psychosis patients and in individuals at clinical high risk for psychosis.The British journal of clinical psychology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent findings suggest that diminished processing of positive contextual information about others during interactions may contribute to social impairment in the schizophrenia spectrum. This could be due to general social context processing deficits or specific biases against positive information. We studied the impact of positive and negative social contextual information during social interactions using functional neuroimaging and probed whether these neural mechanisms were associated with real-life social functioning in schizophrenia spectrum disorders.
methodsPatients with a schizophrenia spectrum disorder (
resultsSocial contextual information had no effect on patients' first investments, whereas controls made the lowest investment after negative and the highest investments after positive contextual information was provided. Over trials, patients decreased investments, suggesting reduced social reward learning, whereas controls increased investments in response to behavioural feedback in the negative context. Patients engaged the dorsolateral prefrontal cortex less than controls during context presentation and showed reduced activity within the caudate during repayments. In patients, lower investments were associated with more time spent alone and social exclusion and lower caudate activation was marginally significantly associated with higher perceived social exclusion.
conclusionThe failure to adapt trust to positive and negative social contexts suggests that patients have a general insensitivity to prior social information, indicating top-down processing impairments. In addition, patients show reduced sensitivity to social reward, i.e. bottom-up processing deficits. Moreover, lower trust and lower neural activation were related to lower real-life social functioning. Together, these findings indicate that improving trust and social interactions in schizophrenia spectrum needs a multi-faceted approach that targets both mechanisms.
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