Evidence map›Paper›PMID 34006086›Full record

ArticleBiochemistry2021

Active Site Hydrogen Bonding Induced in Cytochrome P450cam by Effector Putidaredoxin.

Claire C Mammoser, Sashary Ramos, Megan C Thielges

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claire C MammoserDepartment of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.ORCID 0000-0001-8882-1169
Sashary RamosDepartment of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.
Megan C ThielgesDepartment of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.ORCID 0000-0002-4520-6673
Indiana University Bloomington · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Conformations and Dynamics of Cytochrome P450s via 2D Infrared SpectroscopyR01GM114500 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI THIELGES, MEGAN CORRINE · 2017 to 2022
$1.1M
Graduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926k
NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM114500NIGMS NIH HHS T32 GM109825
6 · The paper itself

Abstract

Cytochrome P450s are diverse and powerful catalysts that can activate molecular oxygen to oxidize a wide variety of substrates. Catalysis relies on effective uptake of two electrons and two protons. For cytochrome P450cam, an archetypal member of the superfamily, the second electron must be supplied by the redox partner putidaredoxin (Pdx). Pdx also plays an effector role beyond electron transfer, but after decades the mechanism remains under investigation. We applied infrared spectroscopy to heme-ligated CN

Indexed as

Bacterial ProteinsCamphorCamphor 5-MonooxygenaseCatalysisCatalytic DomainCrystallography, X-RayCytochrome P-450 Enzyme SystemElectron TransportFerredoxinsHemeHydrogen BondingKineticsModels, MolecularOxidation-ReductionProtein BindingProtein ConformationBacterial ProteinsCamphorCamphor 5-MonooxygenaseCytochrome P-450 Enzyme SystemFerredoxinsHemeputidaredoxin

Identifiers

PMID34006086
PMCPMC8750573
OpenAlexW3163238810

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.