ArticleBMJ open2021
Risk factors for new chronic opioid use after hip fracture surgery: a Danish nationwide cohort study from 2005 to 2016 using the Danish multidisciplinary hip fracture registry.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Reappraising the fascia iliaca compartment block and pericapsular nerve group block for geriatric hip fractures: a narrative review.Journal of anesthesia, analgesia and critical care · 2026Review
- Development and Internal Validation of a Machine Learning Model for Predicting Long-Term Opioid Therapy After Hip Fracture Surgery in Older, Opioid-Naïve Adults.European journal of pain (London, England) · 2026Article
- The persistence of chronic opioid use in patients with inflammatory bowel disease-A nationwide cohort study.British journal of clinical pharmacology · 2026Article
- Chronic opioid prescription in veterans with spinal cord injury: Prevalence and associated factors.The journal of spinal cord medicine · 2025Article
- Socioeconomic Position and Chronic Opioid Use After Hip Fracture Surgery: A Danish Population-Based Cohort Study.European journal of pain (London, England) · 2025Article
- Association of preoperative psychopharmacological treatment and the risk of new chronic opioid use after hip and knee arthroplasty: a Danish registry-based cohort study of 73,033 procedures.Acta orthopaedica · 2025Article
- Trajectories of new opioid use after hip fracture surgery: a population-based cohort study.Pain reports · 2025Article
- Postoperative opioid use in Norway-a population-based observational study on patterns of long-term use.BMC pharmacology & toxicology · 2024Observational
- Use of electronic health record data to examine administrations of pro re nata analgesics during hip fracture post-acute care.Pharmacoepidemiology and drug safety · 2024Article
- Article
- New prolonged opioid consumption after major surgery in Sweden: a population-based retrospective cohort study.BMJ open · 2023Article
- Postoperative opioid prescribing patients with diabetes: Opportunities for personalized pain management.PloS one · 2023Observational
- Opioids and Falls Risk in Older Adults: A Narrative Review.Drugs & aging · 2022Review
- Operative Management of Hip Fractures Within 24 Hours in the Elderly is Achievable and Associated With Reduced Opiate Use.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Persistent postoperative opioid use in patients treated with total hip arthroplasty and hemiarthroplasty for femoral neck fracture: a propensity-score-matched analysis.Canadian journal of surgery. Journal canadien de chirurgieArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the risk factors for new chronic opioid use in elderly patients who underwent hip fracture surgery.
designProspective population-based cohort study. SETTING AND
participantsUsing Danish nationwide health registries, we identified all opioid non-user patients aged ≥65 years who had undergone hip fracture surgery from 2005 to 2016 and were alive within the first year following surgery.
main outcome measuresNew chronic opioid use defined by the dispensing of at least two prescription opioids within two of the last three quarters during the first year following surgery.
resultsWe identified 37 202 opioid non-user patients who underwent hip fracture surgery. Of these, 5497 (15%) developed new chronic opioid user within 1 year of surgery. Risk factors for new chronic opioid use were Body Mass Index (BMI) of <18.5 (adjusted OR (aOR) 1.22, 95% CI 1.09 to 1.36), BMI of 25.0-29.9 (aOR 1.12, 95% CI 1.04 to 1.21) and BMI of ≥30 (aOR 1.57, 95% CI 1.40 to 1.76) with BMI 18.6-24.9 as reference, a pertrochanteric/subtrochanteric fracture (aOR 1.27, 95% CI 1.20 to 1.34) with femoral neck fracture as reference, preoperative use (vs no-use) of non-steroidal anti-inflammatory drug (aOR 1.68, 95% CI 1.55 to 1.83), selective serotonin reuptake inhibitor (aOR 1.42, 95% CI 1.32 to 1.53), antidepressants (aOR 1.36, 95% CI 1.24 to 1.49), antipsychotics (aOR 1.21, 95% CI 1.07 to 1.35), corticosteroids (aOR 1.54, 95% CI 1.35 to 1.76), statins (aOR 1.09, 95% CI 1.02 to 1.18), antibiotics (aOR 1.32, 95% CI 1.22 to 1.42), antiosteoporosis drugs (aOR 1.33, 95% CI 1.19 to 1.49) and anticoagulatives (aOR 1.24, 95% CI 1.17 to 1.32). Presence of cardiovascular comorbidities, diabetes, gastrointestinal diseases, dementia, chronic obstructive pulmonary disease or renal diseases was further identified as a risk factor.
conclusionIn this large nationwide cohort study, we identified several risk factors associated with new chronic opioid use after hip fracture surgery among patients who were alive within the first year following surgery. Although not all factors are modifiable preoperative, this will allow clinicians to appropriately counsel patients preoperatively and tailor postoperative treatment.
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