Evidence map›Paper›PMID 34005032›Full record

ReviewEuropean heart journal2021

Heart healthy cities: genetics loads the gun but the environment pulls the trigger.

Thomas Münzel, Mette Sørensen, Jos Lelieveld, Omar Hahad, Sadeer Al-Kindi, Mark Nieuwenhuijsen, Billie Giles-Corti, Andreas Daiber, Sanjay Rajagopalan

Abstract readReview
In one paragraph

Review in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Journal of the American Heart Association · 2026
    Article
  16. Article
  17. Article
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  19. Comprehensive perceptions at the interface between health and environment: Applications models with a citizen science tool.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas MünzelDepartment of Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID 0000-0001-5503-4150
Mette SørensenDiet, Genes and Environment, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.ORCID 0000-0002-7302-4789
Jos LelieveldAtmospheric Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany.ORCID 0000-0001-6307-3846
Omar HahadDepartment of Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID 0000-0001-7823-7671
Sadeer Al-KindiHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Mark NieuwenhuijsenInstitute for Global Health (ISGlobal), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader 88, 08003 Barcelona, Spain.
Billie Giles-CortiCenter for Urban Research, RMIT University, 124 La Trobe Street, Melbourne VIC 3000, Australia.ORCID 0000-0003-0102-0225
Andreas DaiberDepartment of Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID 0000-0002-2769-0094
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.ORCID 0000-0001-6669-8163

Funding

NIH HHS RO1ES019616
6 · The paper itself

Abstract

The world's population is estimated to reach 10 billion by 2050 and 75% of this population will live in cities. Two-third of the European population already live in urban areas and this proportion continues to grow. Between 60% and 80% of the global energy use is consumed by urban areas, with 70% of the greenhouse gas emissions produced within urban areas. The World Health Organization states that city planning is now recognized as a critical part of a comprehensive solution to tackle adverse health outcomes. In the present review, we address non-communicable diseases with a focus on cardiovascular disease and the urbanization process in relation to environmental risk exposures including noise, air pollution, temperature, and outdoor light. The present review reports why heat islands develop in urban areas, and how greening of cities can improve public health, and address climate concerns, sustainability, and liveability. In addition, we discuss urban planning, transport interventions, and novel technologies to assess external environmental exposures, e.g. using digital technologies, to promote heart healthy cities in the future. Lastly, we highlight new paradigms of integrative thinking such as the exposome and planetary health, challenging the one-exposure-one-health-outcome association and expand our understanding of the totality of human environmental exposures.

Indexed as

Air PollutionHot TemperatureCitiesCity PlanningEnvironmental ExposureHumansUrban HealthAir pollutionEnvironmental stressorsHeart healthy cityHeat islands effectsLight pollutionNoise pollutionUrban and transport planning and design interventions

Identifiers

PMID34005032
PMCPMC8248996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.