Evidence map›Paper›PMID 34004538›Full record

ArticleThe Science of the total environment2021

Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved.

Guangqiang Wang, Hongna Zhang, Jianan Zhang, Katherine Z Sanidad, Vladimir Yeliseyev, Julie Parsonnet, Thomas D Haggerty, Haixia Yang, Lianzhong Ai, Minhao Xie and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Guangqiang WangSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Department of Food Science, University of Massachusetts, Amherst, MA, USA.
Hongna ZhangState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Jianan ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Katherine Z SanidadDepartment of Food Science, University of Massachusetts, Amherst, MA, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.
Vladimir YeliseyevMassachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Julie ParsonnetDepartment of Medicine and Department of Health Research and Policy, Stanford University, Stanford, CA, USA.
Thomas D HaggertyDepartment of Medicine and Department of Health Research and Policy, Stanford University, Stanford, CA, USA.
Haixia YangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Lianzhong AiSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Minhao XieDepartment of Food Science, University of Massachusetts, Amherst, MA, USA; Collaborative Innovation Center for Modern Grain Circulation and Safety, College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China.
Zongwei CaiState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China. Electronic address: zwcai@hkbu.edu.hk.
Guodong ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA. Electronic address: guodongzhang@umass.edu.
University of Massachusetts Amherst · USHong Kong Baptist University · HKStanford University · USBrigham and Women's Hospital · USNanjing University of Finance and Economics · CNUniversity of Shanghai for Science and Technology · CN

Funding

Household Triclosan and Triclocarban Use and the Developing Infant MicrobiomeR21ES023371 · NIEHS · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 2014 to 2016
$974k
NIEHS NIH HHS R21 ES023371
6 · The paper itself

Abstract

Metabolic transformations play critical roles in the bioavailability and toxicities of environmental pollutants and toxicants. However, most previous research has focused on the metabolic reactions in host tissues, the gut microbiota-mediated biotransformation of environmental compounds is understudied. Using triclocarban (TCC) as a model environmental compound, here we study the metabolic fate of TCC in gut tissues and determine the roles of gut microbiota involved. We find that compared with other tissues, the colon tissue has a unique metabolic profile of TCC, with high abundance of the parent compound TCC and its free-form metabolites. Using a variety of approaches including antibiotic-mediated suppression of gut bacteria in vivo, germ-free mice, and in vitro culture of fecal bacteria, we found that the unique metabolic profile of TCC in the colon is mediated by the actions of gut microbiota. Overall, our findings support that gut microbiota plays important roles in colonic metabolism of TCC, highlighting the importance to consider the contributions of gut microbiota in toxicology evaluation of environmental compounds.

Indexed as

CarbanilidesGastrointestinal MicrobiomeAnimalsColonFecesMiceCarbanilidestriclocarbanBiotransformationGut microbiotaMetabolismTriclocarban (TCC)

Identifiers

PMID34004538
PMCPMC8192447
OpenAlexW3162572240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.