Evidence map›Paper›PMID 34004389›Full record

SynthesisJournal of sport and health science2022

Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis.

Xiuxiu Huang, Xiaoyan Zhao, Bei Li, Ying Cai, Shifang Zhang, Qiaoqin Wan, Fang Yu

Registry-linked trialOpen access · diamondAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sport and health science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06927362 (Effects of Lee Silverman Voice Treatment Big and Dual Task Training on Balance, Cognition and Functional Mobility in Older Adults With Cognitive Impairment.), which is not on this map. Cited by 187 papers, 52 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 52 pooled it
32.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06927362 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Lee Silverman Voice Treatment Big and Dual Task Training on Balance, Cognition and Functional Mobility in Older Adults With Cognitive Impairment.

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled50ConditionsCognitive Impairment, Balance Changes, Cognition Disorders in Old Age, Functional MobilityArmsLee Silverman treatment big, Dual task training
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 52 syntheses or guidelines pooled it, 346 citations in OpenAlex.

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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiuxiu HuangSchool of Nursing, Peking University, Beijing 100191, China.
Xiaoyan ZhaoSchool of Nursing, Peking University, Beijing 100191, China.
Bei LiSchool of Nursing, Peking University, Beijing 100191, China.
Ying CaiSchool of Nursing, Peking University, Beijing 100191, China.
Shifang ZhangSchool of Nursing, Peking University, Beijing 100191, China.
Qiaoqin WanSchool of Nursing, Peking University, Beijing 100191, China. Electronic address: qqwan05@163.com.
Fang YuEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004, USA.
Peking University · CNArizona State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise is a promising nonpharmacological therapy for cognitive dysfunction, but it is unclear which type of exercise is most effective. The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment (MCI) or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.

methodsWe searched PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, SPORTDiscus, and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia. Primary outcomes included global cognition, executive cognition, and memory cognition. Secondary outcomes included activities of daily living, neuropsychiatric symptoms, and quality of life. Pairwise analyses and network meta-analyses were performed using a random effects model.

resultsA total of 73 articles from 71 trials with 5606 participants were included. All types of exercise were effective in increasing or maintaining global cognition, and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition (standard mean difference (SMD) = 1.05, 95% confidence interval (95%CI): 0.56-1.54), executive function (SMD = 0.85, 95%CI: 0.21-1.49), and memory function (SMD = 0.32, 95%CI: 0.01-0.63) in patients with cognitive dysfunction. Subgroup analyses for patients with MCI revealed different effects, and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition (SMD = 0.99, 95%CI: 0.44-1.54) and executive function (SMD = 0.72, 95%CI: 0.06-1.38). However, only resistance exercise showed significant effects on memory function for patients with MCI (SMD = 0.35, 95%CI: 0.01-0.69). Exercise interventions also showed various effects on the secondary outcomes.

conclusionResistance exercise has the highest probability of being the optimal exercise type for slowing cognitive decline in patients with cognitive dysfunction, especially in patients with dementia. Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI.

Indexed as

Cognitive DysfunctionDementiaActivities of Daily LivingCognitionExercise TherapyHumansQuality of LifeCognitive functionCognitive impairmentExerciseNetwork meta-analysis

Identifiers

PMID34004389
PMCPMC9068743
OpenAlexW3162566439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.