Evidence map›Paper›PMID 34004262›Full record

ArticleNeuroscience2021

White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.

Kristina L Bell, Juliann B Purcell, Nathaniel G Harnett, Adam M Goodman, Sylvie Mrug, Mark A Schuster, Marc N Elliott, Susan Tortolero Emery, David C Knight

Open access · greenAbstract read
In one paragraph

Article in Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Childhood Opportunity Index 2.0 and Cognition via the NIH Toolbox.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Article
  3. Review
  4. Review
  5. Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kristina L BellDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Juliann B PurcellDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nathaniel G HarnettDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Adam M GoodmanDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sylvie MrugDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mark A SchusterBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Marc N ElliottRAND Corporation, Santa Monica, CA, USA.
Susan Tortolero EmerySchool of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
David C KnightDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: knightdc@uab.edu.
University of Alabama at Birmingham · USHarvard University · USRAND Corporation · USThe University of Texas Health Science Center at Houston · US

Funding

Health Promotion and Disease Prevention Research CentersU48DP000057 · DP · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TORTOLERO, SUSAN · 2004 to 2009
$17.0M
Center for Health Promotion and Disease PreventionU48DP000046 · DP · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MICHAEL, MAX · 2004 to 2009
$8.5M
UCLA/RAND Center for Adolescent Health PromotionU48DP000056 · DP · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAPLAN, ROBERT M · 2004 to 2009
$8.0M
UAB Research Training Program in Neurobiology of Cognition and Cognitive DisordersT32NS061788 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Farah Dominique Lubin · 2008 to 2026
$4.5M
Neurobiological Mechanisms of Lower Internalizing Disorders in Black AmericansR01MH098348 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KNIGHT, DAVID C, MRUG, SYLVIE · 2012 to 2016
$2.9M
Healthy Passages: A Long Term Follow-up Study of Adolescent HealthU19DP002664 · DP · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHUSTER, MARK A. · 2010 to 2011
$1.4M
Healthy PassagesU19DP002663 · DP · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TORTOLERO, SUSAN · 2010 to 2011
$1.4M
Healthy Passages II (Healthy Passages: A Longitudinal Study of Adolescent Health)U19DP002665 · DP · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVIES, SUSAN L · 2010 to 2011
$1.4M
Investigating the Effects of Alcohol and Substance Use During Adolescence Using Multimodal NeuroimagingF31AA027137 · NIAAA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PURCELL, JULIANN B · 2018 to 2020
$110k
NCCDPHP CDC HHS U19 DP002663NCCDPHP CDC HHS U19 DP002664NCCDPHP CDC HHS U19 DP002665NCCDPHP CDC HHS U48 DP000046NCCDPHP CDC HHS U48 DP000056NCCDPHP CDC HHS U48 DP000057NIAAA NIH HHS F31 AA027137NIMH NIH HHS R01 MH098348NINDS NIH HHS T32 NS061788
6 · The paper itself

Abstract

Neighborhood disadvantage and community violence are common in poor, urban communities and are risk factors for emotional dysfunction. Emotional processes are supported by neural circuitry that includes the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Emotional function varies with the microstructure of these white matter pathways. However, it is not clear whether the microstructure of these pathways varies with risk factors for emotional dysfunction (e.g., neighborhood disadvantage and violence exposure). Therefore, determining the relationships between neighborhood disadvantage, violence exposure, and white matter microstructure may offer insight into the neural mechanisms by which adverse life experiences alter developing neural systems. The current study investigated the association that exposure to neighborhood disadvantage and violence have with the quantitative anisotropy (QA), a measure of the amount of directional water diffusion, of the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Neighborhood disadvantage (M

Indexed as

White MatterAdolescentAdultAnisotropyBrainChildDiffusion Tensor ImagingHumansMagnetic Resonance ImagingYoung Adultadolescencediffusion weighted imagingfamily incomeviolence exposure

Identifiers

PMID34004262
PMCPMC8217337
OpenAlexW3162811567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.