Evidence map›Paper›PMID 34004208›Full record

ArticleEuropean journal of pharmacology2021

Stable desensitization of α

Maria Chiara Pismataro, Nicole A Horenstein, Clare Stokes, Clelia Dallanoce, Ganesh A Thakur, Roger L Papke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Differential Activation and Desensitization States Promoted by NoncanonicalThe Journal of pharmacology and experimental therapeutics · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Maria Chiara PismataroDepartment of Pharmaceutical Sciences, Medicinal Chemistry Section "Pietro Pratesi", University of Milan, Via L. Mangiagalli 25, 20133, Milan, Italy; Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611-7200, USA.
Nicole A HorensteinDepartment of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611-7200, USA.
Clare StokesDepartment of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL, 32610-0267, USA.
Clelia DallanoceDepartment of Pharmaceutical Sciences, Medicinal Chemistry Section "Pietro Pratesi", University of Milan, Via L. Mangiagalli 25, 20133, Milan, Italy. Electronic address: clelia.dallanoce@unimi.it.
Ganesh A ThakurDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, 02115, USA.
Roger L PapkeDepartment of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL, 32610-0267, USA.
University of Florida · USUniversity of Milan · ITNortheastern University · US

Funding

Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY024717NIGMS NIH HHS R01 GM057481
6 · The paper itself

Abstract

NS6740 is an α

Indexed as

AcetylcholineAllosteric Regulationalpha7 Nicotinic Acetylcholine ReceptorAnimalsAzabicyclo CompoundsBinding SitesDrug Partial AgonismFuransIsoxazolesMolecular Docking SimulationNicotinic AgonistsPhenylurea CompoundsProtein DomainsSerineXenopus laevis1,4-diazabicyclo(3.2.2)nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)ureaAcetylcholinealpha7 Nicotinic Acetylcholine ReceptorAzabicyclo CompoundsFuransIsoxazolesNicotinic AgonistsPhenylurea CompoundsSerineAllosteric activationDocking analysisPartial agonistSilent agonistSite-directed mutantα(7) nicotinic acetylcholine receptor

Identifiers

PMID34004208
PMCPMC8478151
OpenAlexW3161376902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.