Evidence map›Paper›PMID 34004148›Full record

ArticleDevelopmental cell2021

Narrating the story ARC of adipose tissue aging.

Sean D Kodani, Yu-Hua Tseng

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sean D KodaniSection on Integrative Physiology and Metabolism, Joslin Diabetes Center Harvard Medical School, Boston, MA, USA.
Yu-Hua TsengSection on Integrative Physiology and Metabolism, Joslin Diabetes Center Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: yu-hua.tseng@joslin.harvard.edu.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Role of BMPs in Adipogenesis, Mitochondrial Function and Energy MetabolismR01DK077097 · NIDDK · JOSLIN DIABETES CENTER · PI TSENG, YU-HUA · 2007 to 2019
$5.6M
Fibroblast Growth Factor and Energy MetabolismR01DK102898 · NIDDK · JOSLIN DIABETES CENTER · PI TSENG, YU-HUA · 2015 to 2024
$4.1M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK077097NIDDK NIH HHS R01 DK102898
6 · The paper itself

Abstract

In this issue of Developmental Cell, Nguyen et al. use scRNA-seq to explore the changing cellular landscape of subcutaneous adipose tissue during aging. In the process, they discover a new population of cells called age-dependent regulatory cells (ARC), which contributes to age-related adipose tissue dysfunction that drives metabolic disease.

Indexed as

Adipose TissueCellular Senescence

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.