ArticleImmunity2021
Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed, 29 citations in OpenAlex.
- ID2 orchestrates the final 'E-scape' from the -165-kb Zeb2 enhancer for cDC1 specification.Nature immunology · 2026Article
- ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.Nature immunology · 2026Article
- Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.Science immunology · 2026Article
- Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis.Immunity · 2026Article
- ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropicResearch square · 2025Article
- C/EBPα activatesScience immunology · 2025Article
- Tracing LYVE1bioRxiv : the preprint server for biology · 2025Article
- Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity.Science immunology · 2024Article
- Article
- Transcription factor C/EBPα is required for the development of Ly6CProceedings of the National Academy of Sciences of the United States of America · 2024Article
- CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.Cell death and differentiation · 2024Article
- NR2F6 regulates stem cell hematopoiesis and myelopoiesis in mice.Frontiers in immunology · 2024Article
- CD62L expression marks a functionally distinct subset of memory B cells.Cell reports · 2023Article
- Identification of Cellular Compositions in Different Microenvironments and Their Potential Impacts on Hematopoietic Stem Cells HSCs Using Single-Cell RNA Sequencing with Systematical Confirmation.Life (Basel, Switzerland) · 2023Article
- Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells.Communications biology · 2023Article
- IL-6 selectively suppresses cDC1 specification via C/EBPβ.The Journal of experimental medicine · 2023Article
- Chicken Hypothalamic and Ovarian DNA Methylome Alteration in Response to Forced Molting.Animals : an open access journal from MDPI · 2023Article
- Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state.Molecular cell · 2023Article
- Transcriptional regulation of dendritic cell development and function.Frontiers in immunology · 2023Review
- Article
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Authors and funding
23 authors at 5 institutions in 2 countries.
Xiao HuangDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Stephen T FerrisDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Sunkyung KimDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Mayank N K ChoudharyDepartment of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Julia A BelkDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Changxu FanDepartment of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Yanyan QiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Raki SudanDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Yu XiaDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Pritesh DesaiDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Jing ChenDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Nghi LyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Quanming ShiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Prachi BagadiaDepartment of Oncology, Amgen, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
Tiantian LiuDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Martin GuilliamsUnit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Theresa L MurphyDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ting WangDepartment of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address: kmurphy@wustl.edu.
Washington University in St. Louis · USStanford University · USAmgen (United States) · USGhent University · BEJames S. McDonnell Foundation · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MThe transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6MMolecular Basis of cDC1 DevelopmentR01AI162643 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2025
$2.8M4DN Interrogation of T Cell Exhaustion in CancerU01CA260852 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2020 to 2024
$2.6MFunction of Wdfy4 in cross-presentation and immunityR01AI150297 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2019 to 2023
$2.5MUnderstanding the Mechanisms of DC Licensing in CD8 T Cell PrimingR01CA248919 · NCI · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2025
$2.3MANALYSIS OF BIDIRECTIONAL SIGNALING MECHANISMS FOR BTLA AND HVEM IN AUTOIMMUNITYR01AI076427 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2009 to 2010
$691kSingle cell epigenomics in cancer immunity and immunotherapyK08CA230188 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2018 to 2020
$448kNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS K08 CA230188NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA248919NCI NIH HHS U01 CA260852NIAID NIH HHS R01 AI076427NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI150297NIAID NIH HHS R01 AI162643NIGMS NIH HHS T32 GM007200
Abstract
The transcriptional repressor ZEB2 regulates development of many cell fates among somatic, neural, and hematopoietic lineages, but the basis for its requirement in these diverse lineages is unclear. Here, we identified a 400-basepair (bp) region located 165 kilobases (kb) upstream of the Zeb2 transcriptional start site (TSS) that binds the E proteins at several E-box motifs and was active in hematopoietic lineages. Germline deletion of this 400-bp region (Zeb2
Indexed as
AnimalsCell DifferentiationCell LineageChromatinDendritic CellsEnhancer Elements, GeneticFemaleHematopoiesisHumansMaleMiceMice, Inbred C57BLMonocytesTranscription, GeneticZinc Finger E-box Binding Homeobox 2ChromatinZEB2 protein, mouseZinc Finger E-box Binding Homeobox 2chromatin structureenhancerhematopoiesistranscriptional regulationZeb2zinc finger E-box binding homeobox 2
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