ArticleImmunity2021
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- Serial vaccination expands and refines human CD4bioRxiv : the preprint server for biology · 2026Article
- Gut microbiota: a new factor modulating the immunizing potential of viral and cancer vaccines.Research square · 2025Article
- Activation of PD-1/PD-L1 immune checkpoint by Zika virus.PLoS pathogens · 2025Article
- Longitudinal single cell profiling of epitope specific memory CD4+ T cell responses to recombinant zoster vaccine.Nature communications · 2025Article
- Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations.Cell reports. Medicine · 2025Article
- The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer.Human vaccines & immunotherapeutics · 2024Review
- A guide to adaptive immune memory.Nature reviews. Immunology · 2024Review
- Low-frequency CD8NPJ vaccines · 2024Article
- Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity.JCI insight · 2024Article
- T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector.NPJ vaccines · 2024Article
- Differentiation marker-negative CD4bioRxiv : the preprint server for biology · 2024Article
- The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells.Molecular cancer · 2023Review
- Pre-existing T Cell Memory to Novel Pathogens.ImmunoHorizons · 2023Review
- Anti-tumor memory CD4 and CD8 T-cells quantified by bulk T-cell receptor (TCR) clonal analysis.Frontiers in immunology · 2023Article
- Antigen-specificity measurements are the key to understanding T cell responses.Frontiers in immunology · 2023Review
- SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens.Science immunology · 2022Article
- SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens.bioRxiv : the preprint server for biology · 2021Article
- Large-Scale Structure-Based Screening of Potential T Cell Cross-Reactivities Involving Peptide-Targets From BCG Vaccine and SARS-CoV-2.Frontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Yi-Gen PanDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Benjamas AiamkitsumritDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Laurent BartoloDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yifeng WangDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Criswell LaveryDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA 19104, USA.
Adam MarcDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA 19104, USA.
Patrick V HolecDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
C Garrett RappazzoDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Theresa EilolaDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Phyllis A GimottyDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rustom AntiaDepartment of Biology, Emory University, Atlanta, GA, USA.
Veronika I ZarnitsynaDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Michael E BirnbaumDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Laura F SuDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA 19104, USA. Electronic address: laurasu@upenn.edu.
University of Pennsylvania · USMassachusetts Institute of Technology · USPhiladelphia VA Medical Center · USEmory University · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Darrell J Irvine · 1985 to 2026
$93.9MDefining the impact of pre-existing memory T cells in human immunityR01AI134879 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SU, LAURA · 2017 to 2021
$2.5MDefining how Microbes Drive Abnormal T Cell Responses in Rheumatoid ArthritisI01CX001460 · VA · PHILADELPHIA VA MEDICAL CENTER · PI Laura Su · 2016 to 2026
–CSRD VA I01 CX001460NCI NIH HHS P30 CA014051NIAID NIH HHS R01 AI134879
Abstract
We examined how baseline CD4
Indexed as
AdultAnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCD4-Positive T-LymphocytesCells, CulturedChlorocebus aethiopsHumansReceptors, Antigen, T-CellVaccinationVero CellsYellow FeverYellow Fever VaccineYellow fever virusAntibodies, NeutralizingAntibodies, ViralAntigens, ViralReceptors, Antigen, T-CellYellow Fever VaccineCD4+clonal selectionimmunological memorypre-existing T cellsrepertoire diversityT cellsTCRtetramersunexposed humanvaccineyellow fever virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.