ReviewNeuron2021
How does hemispheric specialization contribute to human-defining cognition?
Review in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Individual sedentary activities and cognitive function in middle-aged and older adults: A systematic review.Journal of Alzheimer's disease : JAD · 2026Pooled it
- The Detrimental Effect of Stroke on Motor Adaptation.Neurorehabilitation and neural repair · 2025Pooled it
- Efficacy of transcranial magnetic stimulation for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Interhemispheric Metabolic Effects of Transcranial Infrared Laser Stimulation of the Prefrontal Cortex.Human brain mapping · 2026Trial
- Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks.Annals of medicine · 2026Article
- Left-lateralized glymphatic dysfunction is associated with MoCA-measured cognitive impairment in cerebral small vessel disease: A DTI-ALPS study.IBRO neuroscience reports · 2026Article
- Targeting the posterior thalamic hub: hemispheric-specific encoding of pain-depression comorbidity after hemorrhagic stroke.BMC medicine · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Spatial connectivity for local cortical homogeneity.Research square · 2026Article
- Developmental disinhibition gates language lateralization in childhood.Nature communications · 2026Article
- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Bridging glucose metabolism and intrinsic functional organization of the human cortex.Communications biology · 2026Article
- Does white matter structure relate to hemispheric language lateralization? A systematic review.Brain communications · 2026Review
- Characterizing Ultimatum Game responders: a scoping review of factors that influence decision-making through an evolutionary lens.Frontiers in psychology · 2026Review
- A comprehensive investigation into EEG spectral analysis for ADHD brain dominance.AIMS neuroscience · 2026Article
- Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Lateralization Disruption and Dynamic Balance Alterations in Alzheimer's Disease: Impacts on Hemispheric Interaction and Cognitive Performance.Human brain mapping · 2025Article
- Spacetime concordance in the primate cortex.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal changes in brain asymmetry track lifestyle and disease.Nature communications · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Uniquely human cognitive faculties arise from flexible interplay between specific local neural modules, with hemispheric asymmetries in functional specialization. Here, we discuss how these computational design principles provide a scaffold that enables some of the most advanced cognitive operations, such as semantic understanding of world structure, logical reasoning, and communication via language. We draw parallels to dual-processing theories of cognition by placing a focus on Kahneman's System 1 and System 2. We propose integration of these ideas with the global workspace theory to explain dynamic relay of information products between both systems. Deepening the current understanding of how neurocognitive asymmetry makes humans special can ignite the next wave of neuroscience-inspired artificial intelligence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.