ArticleTranslational vision science & technology2021
Abnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosis.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Retinal optical coherence tomography measures in multiple sclerosis: a systematic review and meta-analysis.Annals of clinical and translational neurology · 2024Pooled it
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Quantitative automated pupillometry in diabetic patients and correlation with retinal nerve fibre layer thickness.Eye (London, England) · 2025Article
- Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers.Eye (London, England) · 2024Review
- Basics, benefits, and pitfalls of pupillometers assessing visual function.Eye (London, England) · 2024Review
- Observational
- Dynamic Pupillary Response in Multiple Sclerosis Patients with and without Optic Neuritis.Biomedicines · 2023Article
- Rapid, non-contact multifocal visual assessment in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation.Frontiers in neurology · 2023Review
- Objective perimetry and progression of multiple sclerosis.eNeurologicalSci · 2022Article
- Abnormal quantitative pupillary light responses following COVID-19.International ophthalmology · 2022Article
- Photopic negative response recorded with RETeval system in eyes with optic nerve disorders.Scientific reports · 2022Article
- Dynamic and Static Pupil Changes After Near Work: Comparison Between Reading a Book and Using a Smartphone.Beyoglu eye journal · 2022Article
- Corneal Confocal Microscopy to Image Small Nerve Fiber Degeneration: Ophthalmology Meets Neurology.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To assess alterations in quantitative dynamic pupil responses to light in relation to neurologic disability and retinal axonal loss in patients with multiple sclerosis (MS). Methods: Twenty-five patients with relapsing-remitting MS and 25 healthy subjects were included in this cross-sectional study. Pupillary responses were measured with an infrared dynamic pupillometry unit, and peripapillary retinal nerve fiber layer (RNFL) thickness was measured with spectral-domain optical coherence tomography. Neurologic disability was assessed by the Expanded Disability Status Scale (EDSS). Patients with a history of optic neuritis (ON) within 6 months were excluded. Only the right eyes were assessed, except in 11 patients with a history of unilateral ON in whom both eyes were further analyzed to evaluate the effect of previous ON. Results: The initial pupil diameter (P = 0.003) and pupil contraction amplitude (P = 0.027) were lower in patients with MS compared with healthy controls. Initial pupil diameter correlated with EDSS score (ρ = -0.458; P = 0.021), and RNFL correlated with contraction latency (ρ = -0.524; P = 0.007). There were no significant differences in any of the pupil parameters between eyes with and without a history of ON, and between the ON and fellow eyes of the 11 patients with previous unilateral ON. Conclusions: Dynamic pupillometry reveals significant alterations in pupillary light reflex responses associated with neurologic disability and retinal axonal loss, independent of previous ON. Translational Relevance: Dynamic pupillometry is a simple, noninvasive tool that may be useful in detecting autonomic dysfunction in patients with MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.