ArticleTranslational vision science & technology2021
Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Cross-Device Field-of-View Scale Differences in Clinical OCT Angiography: Phantom Calibration and Large-Scale Clinical Validation.medRxiv : the preprint server for health sciences · 2026Article
- Novel Quantitative Metrics for Foveal Hypoplasia Derived from Optical Coherence Tomography Angiography Using AngioTool.Journal of clinical medicine · 2026Article
- Image Quality as an Important Confounder in Quantitative OCT Angiography: A Review with Quantitative Synthesis.Medical sciences (Basel, Switzerland) · 2026Review
- Sympathetic Stress and Sleep Loss in Diabetic Retinopathy: Links to Retinal Blood-Flow Control.Biomedicines · 2026Review
- One-Year Progression of Capillary Nonperfusion in Nonproliferative Diabetic Retinopathy Using Noninvasive Imaging: The CHART Study.Translational vision science & technology · 2026Observational
- Unsupervised quality assessment with generative adversarial networks for 3D OCTA microvascular imaging.Biomedical optics express · 2026Article
- The Artifacts in Macular and Peripapillary OCT Angiography in Patients with Different Severities of Glaucoma.Ophthalmology science · 2026Article
- Ultra-Widefield Retinal Optical Coherence Tomography (OCT) and Angio-OCT Using an Add-On Lens.Diagnostics (Basel, Switzerland) · 2025Article
- Intersession repeatability of visual function and OCTA metrics in eyes with diabetic macular ischaemia.Eye (London, England) · 2025Article
- Astigmatism Influences Quantitative and Qualitative Analysis in Optical Coherence Tomography Angiography Imaging.Translational vision science & technology · 2024Article
- Factors affecting optical coherence tomography angiography signal strength index in patients receiving intravitreal injection treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.Neurology(R) neuroimmunology & neuroinflammation · 2023Review
- Assessing the Sensitivity of OCT-A Retinal Vasculature Metrics.Translational vision science & technology · 2023Article
- Convolutional Neural Network-Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals With Neurodegenerative Disease.Translational vision science & technology · 2023Article
- A fluorescein angiography-based computer-aided algorithm for assessing the retinal vasculature in diabetic retinopathy.Eye (London, England) · 2023Article
- Deep Learning in Optical Coherence Tomography Angiography: Current Progress, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Long-Term Variations in Retinal Parameters after Uncomplicated Cataract Surgery.Journal of clinical medicine · 2022Article
- Quantification of Nonperfusion Area in Montaged Widefield OCT Angiography Using Deep Learning in Diabetic Retinopathy.Ophthalmology science · 2021Article
- OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Purpose: To explore optical coherence tomography angiography (OCTA) quality and associated factors in multicenter clinical studies. Methods: OCTA scans were obtained from participants with diabetic retinopathy from three DRCR Retina Network clinical studies using the Optovue AngioVue and ZEISS AngioPlex. Macular (3 × 3 mm and 6 × 6 mm) and optic nerve scans were captured. Quality was assessed by the Casey Reading Center. Scans were considered "poor" if the signal strength index (SSI) was less than 55 (AngioVue) or 7 (AngioPlex) or if excess motion, media opacities, beam defocus, incorrect axial position, or other artifacts were present. Results: Included were 7539 scans from 787 eyes (461 participants). Sixty-one percent of scans were considered "good" (n = 4630). Of the 3 × 3-mm (n = 2294), 6 × 6-mm (n = 2705), and optic nerve scans (n = 2540), 62%, 63%, and 59%, respectively, were good. Differences in percentage of good scans by machine were not identified (61% of 6216 for the AngioVue and 63% of 1323 for the AngioPlex). The primary reason for poor scans was low SSI for the AngioVue (67%) and excess motion for the AngioPlex (47%). Good scans were associated with younger age (60 ± 12 years vs. 65 ± 11 years; P < 0.001), male gender (64% of males had good scans vs. 57% female; P = 0.007), and better visual acuity (ETDRS letter score 86.5 ± 6.4 [approximate Snellen equivalent 20/20] vs. 81.6 ± 9.7 [approximate Snellen equivalent 20/25]; P < 0.001). Conclusions: Scan quality or analysis must be improved for OCTA metrics to be used as outcomes in future research. Translational Relevance: Clinicians and researchers should be aware that poor SSI and artifacts are common issues for OCTA images.
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Registered trials
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