Evidence map›Paper›PMID 34003921›Full record

ArticleTranslational vision science & technology2021

Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling.

Lekha K Mukkamala, Jaycob Avaylon, R Joel Welch, Amirfarbod Yazdanyar, Parisa Emami-Naeini, Sophia Wong, Jordan Storkersen, Jessica Loo, David Cunefare, Sina Farsiu and 3 more

Abstract read
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In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lekha K MukkamalaDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Jaycob AvaylonCalifornia Northstate University, College of Medicine, Elk Grove, CA, USA.
R Joel WelchDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Amirfarbod YazdanyarDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Parisa Emami-NaeiniDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Sophia WongDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Jordan StorkersenCalifornia Northstate University, College of Medicine, Elk Grove, CA, USA.
Jessica LooDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
David CunefareDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Sina FarsiuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Ala MoshiriDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Susanna S ParkDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Glenn YiuDepartment of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.

Funding

The Role of ARAP1 in Retinal Photoreceptor HomeostasisK08EY027463 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOSHIRI, ALA · 2017 to 2021
$1.0M
NEI NIH HHS K08 EY027463
6 · The paper itself

Abstract

Purpose: To investigate whether intraoperative retinal changes during epiretinal membrane (ERM) peeling affect anatomic or functional outcomes after surgery. Methods: We measured retinal thickness using an intraoperative optical coherence tomography (iOCT) device in patients undergoing pars plana vitrectomy with membrane peeling for idiopathic ERM. Changes in intraoperative central macular thickness (iCMT) were compared with postoperative improvements in CMT and best-corrected visual acuity (VA). Results: Twenty-seven eyes from 27 patients (mean age 68 years) underwent iOCT-assisted ERM peeling surgery. Before surgery, mean VA was logMAR 0.50 ± 0.36 (Snellen 20/63), and mean baseline CMT was 489 ± 82 µm. Mean iCMT before peeling was 477 ± 87 µm, which correlated well with preoperative CMT (P < 0.001). Mean change in iCMT was -39.6 ± 37 µm (range -116 to +77 µm). After surgery, VA improved to logMAR 0.40 ± 0.38 (Snellen 20/50) at month 1 and logMAR 0.27 ± 0.23 (Snellen 20/37) at month 3, whereas CMT decreased to 397 ± 44 µm and 396 ± 51 µm at months 1 and 3. Eyes that underwent greater amount of iCMT change (absolute value of iCMT change) were associated with greater CMT reduction at month 1 (P < 0.001) and month 3 (P = 0.010), whereas those with greater intraoperative thinning (actual iCMT change) showed a trend toward better VA outcomes at months 1 (P = 0.054) and 3 (P = 0.036). Conclusions: Intraoperative changes in retinal thickness may predict anatomic and visual outcomes after idiopathic ERM peeling surgery. Translational Relevance: Our study suggests that intraoperative retinal tissue response to ERM peeling surgery measured by iOCT may be a prognostic indicator for restoration of retinal architecture and for visual acuity outcomes.

Indexed as

Epiretinal MembraneAgedHumansRetinaRetrospective StudiesTreatment OutcomeVitrectomy

Identifiers

PMID34003921
PMCPMC7910632

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.