Evidence map›Paper›PMID 34003909›Full record

ArticleTranslational vision science & technology2021

White Paper on Ophthalmic Imaging for Choroidal Nevus Identification and Transformation into Melanoma.

Carol L Shields, Sara E Lally, Lauren A Dalvin, Mandeep S Sagoo, Marco Pellegrini, Swathi Kaliki, Ahmet Kaan Gündüz, Minoru Furuta, Prithvi Mruthyunjaya, Adrian T Fung and 6 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
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  8. Automated segmentation for early detection of uveal melanoma.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024
    Article
  9. Advances in multimodal imaging for diagnosis of pigmented ocular fundus lesions.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024
    Review
  10. Article
  11. Article
  12. Multispectral Fundus Photography of Choroidal Nevi with Trans-Palpebral Illumination.medRxiv : the preprint server for health sciences · 2024
    Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 7 countries.

Carol L ShieldsOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Sara E LallyOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Lauren A DalvinDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Mandeep S SagooOcular Oncology Service, Moorfields Eye Hospital and NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Marco PellegriniEye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
Swathi KalikiThe Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.
Ahmet Kaan GündüzDepartment of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
Minoru FurutaDepartment of Ophthalmology, Fukushima Medical University, Fukushima, Japan and Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Tokyo, Japan.
Prithvi MruthyunjayaOcular Oncology Service, Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Adrian T FungWestmead and Central Clinical Schools, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Australia and Department of Ophthalmology, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Jay S DukerNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Sara M SeligMelanoma Research Foundation, Washington, DC, USA.
Antonio YaghyOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Sandor R FerenczyOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Malvina B EydelmanOffice of Ophthalmic, Anesthesia, Respiratory, Ear, Nose and Throat (ENT), and Dental Devices, Food & Drug Administration (FDA), Washington, DC.
Mark S BlumenkranzDepartment of Ophthalmology, Ophthalmology Innovation Program, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Stanford University · USThomas Jefferson University · USWills Eye Hospital · USAnkara University · TRLuigi Sacco Hospital · ITL V Prasad Eye Institute · INMayo Clinic in Arizona · USMelanoma Research Foundation · USTokyo Women's Medical University · JPTufts Medical Center · USUnited States Food and Drug Administration · USUniversity College London · GBUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To discuss the evolution of noninvasive diagnostic methods in the identification of choroidal nevus and determination of risk factors for malignant transformation as well as introduce the novel role that artificial intelligence (AI) can play in the diagnostic process. Methods: White paper. Results: Longstanding diagnostic methods to stratify benign choroidal nevus from choroidal melanoma and to further determine the risk for nevus transformation into melanoma have been dependent on recognition of key clinical features by ophthalmic examination. These risk factors have been derived from multiple large cohort research studies over the past several decades and have garnered widespread use throughout the world. More recent publications have applied ocular diagnostic testing (fundus photography, ultrasound examination, autofluorescence, and optical coherence tomography) to identify risk factors for the malignant transformation of choroidal nevus based on multimodal imaging features. The widespread usage of ophthalmic imaging systems to identify and follow choroidal nevus, in conjunction with the characterization of malignant transformation risk factors via diagnostic imaging, presents a novel path to apply AI. Conclusions: AI applied to existing ophthalmic imaging systems could be used for both identification of choroidal nevus and as a tool to aid in earlier detection of transformation to malignant melanoma. Translational Relevance: Advances in AI models applied to ophthalmic imaging systems have the potential to improve patient care, because earlier detection and treatment of melanoma has been proven to improve long-term clinical outcomes.

Indexed as

MelanomaNevusSkin NeoplasmsArtificial IntelligenceHumansTomography, Optical Coherence

Identifiers

PMID34003909
PMCPMC7900849
OpenAlexW3129561094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.