ArticleTranslational vision science & technology2021
Correlation of Central Versus Peripheral Macular Structure-Function With Acuity in Age-Related Macular Degeneration.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Lesion detection in age-related macular degeneration with a multi-modal imaging and machine learning approach.Biomedical engineering online · 2025Article
- Objective perimetry and diabetic retinopathy progression: a 10-year follow-up study.Frontiers in endocrinology · 2025Article
- Regression of the Flow Signal from the Neovascular Network in AMD Neovascular Membranes Treated with Faricimab.Diagnostics (Basel, Switzerland) · 2024Article
- Visual Field Tests: A Narrative Review of Different Perimetric Methods.Journal of clinical medicine · 2024Review
- Defining the structure-function relationship of specific lesions in early and advanced age-related macular degeneration.Scientific reports · 2024Article
- Structure-Function Relationship in Keratoconus: Spatial and Depth Vision.Translational vision science & technology · 2023Article
- Location of Retinal Pigment Epithelial Cells in the Eye Is Critical to Their Function.The American journal of pathology · 2023Article
- Age-Related Macular or Retinal Degeneration?Medicina (Kaunas, Lithuania) · 2023Review
- Retinal Pigment Epithelial Abnormality and Choroidal Large Vascular Flow Imbalance Are Associated with Choriocapillaris Flow Deficits in Age-Related Macular Degeneration in Fellow Eyes.Journal of clinical medicine · 2023Article
- Discriminating early-stage diabetic retinopathy with subjective and objective perimetry.Frontiers in endocrinology · 2023Article
- Rapid, non-contact multifocal visual assessment in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema.PloS one · 2023Article
- Objective perimetry and progression of multiple sclerosis.eNeurologicalSci · 2022Article
- Progress of Diabetic Macular Edema after Loading Injection of Anti-Vascular Endothelial Growth Factor Agents in Real-World Cases.Medicina (Kaunas, Lithuania) · 2022Observational
- Foveolar thickness as potential standardized structural outcome measurement in studies of Bietti crystalline dystrophy.Scientific reports · 2022Article
- Rapid Objective Testing of Visual Function Matched to the ETDRS Grid and Its Diagnostic Power in Age-Related Macular Degeneration.Ophthalmology science · 2022Article
- An Objective Perimetry Study of Central Versus Peripheral Sensitivities and Delays in Age-Related Macular Degeneration.Translational vision science & technology · 2021Article
- Comparing Objective Perimetry, Matrix Perimetry, and Regional Retinal Thickness in Mild Diabetic Macular Edema.Translational vision science & technology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Patients with advanced age-related macular degeneration (AMD) may have preserved visual function despite significant retinal structural changes. We aimed to evaluate the relationships among retinal thickness, macular sensitivity, and visual acuity (VA) in advanced AMD. Methods: We examined 43 eyes of 22 patients with advanced AMD (ages 66-93 years), prospectively recruited from the Canberra Hospital Ophthalmology Department. Visual function was measured on participants with low and high contrast visual acuity (LCVA and HCVA) and 10-2 Matrix visual fields. Retinal structure was determined with spectral domain optical coherence tomography (OCT), and customized software mapped the 64 OCT macular thickness regions onto the 44 regions of the 10-2 test. Results: Median retinal thickness at each 10-2 region was near normal. Just 7 of 88 regions from the OCT analysis that were thicker than the median had sensitivity that declined significantly with increasing thickness (r = -0.698 ± 0.082, mean ± SD), whereas 17 of 88 thinner regions showed significantly decreasing sensitivity with decreasing thickness (r = 0.723 ± 0.078). The absolute value of deviations from median optical coherence tomography thickness (aOCT) outside the central eight degrees was significantly correlated with HCVA (r = -0.34, P = 0.047). Thickness in the central eight degrees was not. Similarly, matrix sensitivities inside the central eight degrees were significantly correlated with outer aOCT (r = -0.49, P = 0.002). Conclusions: Retinal thickness outside eight degrees were significantly associated with HCVA and macular sensitivity. These results suggest that outer macular thickness may be a useful prognostic indicator in AMD. Translational Relevance: Retinal structure at the borders of the macula may be a surrogate marker of vision and retinal thickness near fixation.
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