ArticleTranslational vision science & technology2021
Associations Between Capillary Diameter, Capillary Density, and Microaneurysms in Diabetic Retinopathy: A High-Resolution Confocal Microscopy Study.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 40 citations in OpenAlex.
- Retinal Capillary Loss Is More Severe in the Midperiphery Than in the Macula in Eyes With Diabetic Retinopathy Compared to Healthy Eyes.Translational vision science & technology · 2026Article
- Validation of Deep Capillary Plexus OCTA Metrics as Predictors of Diabetic Retinopathy Complications: A One-Year Longitudinal Study.Research square · 2026Article
- Multiparametric OCTA Biomarkers for Classifying Mild Diabetic Retinopathy: A Cross-Sectional Evaluation.Translational vision science & technology · 2026Article
- Article
- Quantitative assessment of age-related retinal and choriocapillaris blood flow changes in a healthy Korean population using optical coherence tomography angiography.Scientific reports · 2026Article
- Baseline Nonperfusion and Deep Capillary Plexus Ischemia Predict Two-Year Retinal Nonperfusion Progression in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Observational
- Retinal Perfusion and Injury in Sepsis and after Major Surgery.Ophthalmology science · 2026Article
- One year of hyperglycemia in the Ins2Akita mouse does not impart changes in retinal vascular patterning.PloS one · 2026Article
- Investigating Late-Stage Diabetic Retinopathy: A Long-term Analysis of Vascular Changes in the Streptozotocin-Induced Mouse Model.Diabetes · 2025Article
- Generation of vascularized retinal organoids containing microglia based on a PDMS microwell platform.Science advances · 2025Article
- Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.Journal of biomechanical engineering · 2025Article
- Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation.Journal of diabetes research · 2025Article
- Characterization of the Retinal Circulation of the Mouse.Investigative ophthalmology & visual science · 2024Article
- Interpericyte Tunneling Nanotubes Are Nonuniformly Distributed in the Human Macula.Investigative ophthalmology & visual science · 2024Article
- Digital histology of retinal microaneurysms as provided by dense B-scan (DART) OCTA: characteristics and clinical relevance in diabetic retinopathy.Eye (London, England) · 2024Observational
- Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.bioRxiv : the preprint server for biology · 2024Article
- Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys.bioRxiv : the preprint server for biology · 2024Article
- Retinal vasculature of different diameters and plexuses exhibit distinct vulnerability in varying severity of diabetic retinopathy.Eye (London, England) · 2024Article
- The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure.Investigative ophthalmology & visual science · 2024Article
- Linking Vascular Structure and Function: Image-Based Virtual Populations of the Retina.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To use high-resolution histology to define the associations between microaneurysms, capillary diameter and capillary density alterations in diabetic retinopathy (DR). Methods: Quantitative comparisons of microaneurysm number, capillary density and capillary diameter were performed between eight human donor eyes with nonproliferative DR and six age- and eccentricity-matched normal donor eyes after retinal vascular perfusion labelling. The parafovea, 3-mm, 6-mm, and 9-mm retinal eccentricities were analyzed and associations between microvascular alterations defined. Results: Mean capillary density was reduced in all retina regions in the DR group (P = 0.013). Microaneurysms occurred in all retina regions in the DR group, but the association between decreased capillary density and microaneurysm number was only significant in the 3-mm (P = 0.040) and 6-mm (P = 0.007) eccentricities. The mean capillary diameter of the DR group (8.9 ± 0.53 µm) was greater than the control group (7.60 ± 0.40 µm; P = 0.033). There was no association between capillary diameter increase and capillary density decrease (P = 0.257) and capillary diameter increase and microaneurysm number (P = 0.147) in the DR group. Within the parafovea of the DR group, capillary density was significantly reduced, and capillary diameter was significantly increased in the deep capillary plexus compared with the superficial and intermediate plexuses (all P < 0.05). Conclusions: In DR, capillary density reduction occurs across multiple retina eccentricities with a predilection for the deep capillary plexus. The association between microaneurysm number and capillary density is specific to retina eccentricity. Capillary diameter increase may be an early biomarker of DR. These findings may refine the application of optical coherence tomography angiography techniques for the management of DR.
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