Evidence map›Paper›PMID 34003742›Full record

ArticleeLife2021

Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls

John A Buglino, Gaurav D Sankhe, Nathaniel Lazar, James M Bean, Michael S Glickman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  7. Review
  8. Review
  9. Vaccines · 2024
    Article
  10. The role of transcriptional regulators in metal ion homeostasis ofFrontiers in cellular and infection microbiology · 2024
    Review
  11. Article
  12. MedComm · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. ECF Sigma Factor HxuI Is Critical forMicrobiology spectrum · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

John A BuglinoImmunology Program Sloan Kettering Institute, New York City, United States.ORCID 0000-0001-8961-8672
Gaurav D SankheImmunology Program Sloan Kettering Institute, New York City, United States.ORCID 0000-0002-5627-2879
Nathaniel LazarImmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York City, United States.
James M BeanImmunology Program Sloan Kettering Institute, New York City, United States.ORCID 0000-0001-6733-5794
Michael S GlickmanImmunology Program Sloan Kettering Institute, New York City, United States.ORCID 0000-0001-7918-5164
Kettering University · USCornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Rip1 controlled stress resistance and virulence in Mycobacterium tuberculosisR01AI138446 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI GLICKMAN, MICHAEL S · 2019 to 2023
$2.3M
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI138446
6 · The paper itself

Abstract

Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For

Indexed as

AnimalsBacterial ProteinsCopperDisease Models, AnimalGene Expression Regulation, BacterialHistidine KinaseHost-Pathogen InteractionsLungMacrophagesMiceMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisNitric OxideNitric Oxide Synthase Type IIPeptide HydrolasesBacterial ProteinsCopperHistidine KinaseNitric OxideNitric Oxide Synthase Type IINos2 protein, mousePeptide Hydrolasesbacterial pathogenesisinfectious diseasemicrobiologyM. tuberculosisnutritional immunitysignal transductiontuberculosis

Identifiers

PMID34003742
PMCPMC8131098
OpenAlexW3163253204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.