ArticleJournal of diabetes investigation2021
Islet β-cells physiological difference study of old and young mice based on single-cell transcriptomics.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Unveiling the Hub Genes Associated with the Enhanced Effects of Selenium on Pancreas Function in Diabetic Mice.Molecular biotechnology · 2026Article
- Novel Four-gene Panel for Detecting Senescence-associated Cell States in Skeletal Muscle Tissue.Juntendo medical journal · 2026Article
- Single-cell transcriptomic atlas of taste papilla aging.Aging cell · 2024Article
- Pleiotrophin Expression and Actions in Pancreatic β-Cells.Frontiers in endocrinology · 2022Article
- Islet β-cells physiological difference study of old and young mice based on single-cell transcriptomics.Journal of diabetes investigation · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionBody aging is a universal biological process. With aging, cells undergo a series of physiological changes. The main feature is cell proliferation decline, although the cells still have normal functions. Pancreatic β-cells are no exception. However, the physiological senescence of β-cells, and the resulting function and transcriptome changes have rarely attracted attention. The specific senescence phenotype of β-cells remains unknown. MATERIALS AND
methodsPancreatic samples from three female C57BL/6 mice with aged 2.5 months (young) mice and 20 months (old) were digested to a single-cell suspension and analyzed, with 10× Genomics single-cell ribonucleic acid sequencing, β-cells were determined by biosynthesis analysis, and differences between old and young mice were identified.
resultsA total of 47 differential genes with significant and statistical significance were screened in β-cells (fold change >1.5, P < 0.05). In old mice, 27 genes were upregulated and 20 genes were downregulated. Genes Mt1, Mt2, Pyy, Gcg and Pnlip, and mitochondrial genes mt-Nd1, mt-Nd3, mt-Co1, mt-Co2 and mt-Co3 were found to be involved in cellular senescence. Transcription factors Jund and Fos were important regulators of senescence.
conclusionsAn overall difference was found between the pancreatic β-cells of old and young mice. Transcription factors facilitate transitions between pancreatic β-cells. These findings are worthy of deep exploration, and provide new resources and directions for the research of pancreatic aging in mice.
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