Evidence map›Paper›PMID 34003373›Full record

ArticleJournal of neurology2022

Subthalamic deep brain stimulation affects heading perception in Parkinson's disease.

Sinem Balta Beylergil, Angela M Noecker, Mikkel Petersen, Palak Gupta, Sarah Ozinga, Mark F Walker, Camilla Kilbane, Cameron C McIntyre, Aasef G Shaikh

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sinem Balta BeylergilDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Angela M NoeckerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Mikkel PetersenDepartment of Clinical Medicine-Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Palak GuptaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Sarah OzingaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Mark F WalkerNational VA Parkinson Consortium Center, Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Camilla KilbaneDepartment of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA.
Cameron C McIntyreDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Aasef G ShaikhDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. aasefshaikh@gmail.com.ORCID http://orcid.org/0000-0003-4781-7176
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USAarhus University · DKThe Neurological Institute · USUniversity Hospitals of Cleveland · US

Funding

Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.I01CX002086 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI SHAIKH, AASEF G · 2021 to 2024
–
CSRD VA I01 CX002086
6 · The paper itself

Abstract

Parkinson's disease (PD) presents with visuospatial impairment and falls. It is critical to understand how subthalamic deep brain stimulation (STN DBS) modulates visuospatial perception. We hypothesized that DBS has different effects on visual and vestibular perception of linear motion (heading), a critical aspect of visuospatial navigation; and such effects are specific to modulated STN location. Two-alternative forced-choice experiments were performed in 14 PD patients with bilateral STN DBS and 19 age-matched healthy controls (HC) during passive en bloc linear motion and 3D optic-flow in immersive virtual reality measured vestibular and visual heading. Objective measure of perception with Weibull psychometric function revealed that PD has significantly lower accuracy [L: 60.71 (17.86)%, R: 74.82 (17.44)%] and higher thresholds [L: 16.68 (12.83), R: 10.09 (7.35)] during vestibular task in both directions compared to HC (p < 0.05). DBS significantly improved vestibular discrimination accuracy [81.40 (14.36)%] and threshold [4.12 (5.87), p < 0.05] in the rightward direction. There were no DBS effects on the slopes of vestibular psychometric curves. Visual heading perception was better than vestibular and it was comparable to HC. There was no significant effect of DBS on visual heading response accuracy or discrimination threshold (p > 0.05). Patient-specific DBS models revealed an association between change in vestibular heading perception and the modulation of the dorsal STN. In summary, DBS may have different effects on vestibular and visual heading perception in PD. These effects may manifest via dorsal STN putatively by its effects on the cerebellum.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusVestibule, LabyrinthHumansVisual PerceptionBasal gangliaCerebellumMotion perceptionOptic flowVestibularVisual

Identifiers

PMID34003373
OpenAlexW3161911284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.